In Vitro Gastrointestinal Release of Chlorogenic Acid and Curcumin Co-Encapsulated in Double Emulsions with the Outer Interface Stabilized by Cellulose Nanocrystals

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dc.coverageDOI: 10.3390/colloids8020024
dc.creatorParedes-Toledo, Javier
dc.creatorHerrera, Javier
dc.creatorDíaz-Calderón, Paulo
dc.creatorRobert, Paz
dc.creatorGiménez, Begoña
dc.date2024
dc.date.accessioned05-01-2026 18:14
dc.date.available05-01-2026 18:14
dc.description<p>A Pickering double emulsion (DE) with an outer (O:W<sub>2</sub>) interface stabilized by cellulose nanocrystals (DE-CNC) was designed as a co-delivery systems for chlorogenic acid (CA) and curcumin, then compared with a control DE emulsion with an O:W<sub>2</sub> interface stabilized with sodium caseinate (DE-NaCas). DE-CNC was more resistant to creaming during storage (6.79%, day 42) and showed higher encapsulation efficiency (EE) of CA (&gt;90%). Conversely, both DEs exhibited similarly high EE for curcumin (&gt;97%). The ?-potential values were highly negative in both DEs, but tended to be lower in DE-CNC due to the highly negative charge of the CNCs. DE-CNC allowed for a steady release of CA during the oral, gastric, and intestinal phases of digestion, while a total release of CA was already observed in the gastric phase in case of DE-NaCas. The bioaccessibility of CA was similar in both DEs (~57–58%). Curcumin was mainly released in the intestinal phase with both DEs, reaching slightly lower bioaccessibility values with DE-CNC. The use of CNCs as a stabilizer for the outer interface of DEs is a promising strategy to increase the stability and EE of these systems, providing oral co-delivery vehicles capable of releasing significantly bioactive compounds during the intestinal phase of digestion.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/535d1925-deb3-4bfd-a590-1f5671fb9d35
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.8 (2024) nr.2 p.1-18
dc.subjectPickering double emulsion
dc.subjectcellulose nanocrystals
dc.subjectchlorogenic acid
dc.subjectco-delivery
dc.subjectcurcumin
dc.subjectin vitro digestion
dc.titleIn Vitro Gastrointestinal Release of Chlorogenic Acid and Curcumin Co-Encapsulated in Double Emulsions with the Outer Interface Stabilized by Cellulose Nanocrystalseng
dc.typeArticleeng
dc.typeArtículospa
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