Effect of M-wave Amplitude on Inter-evaluator Concordance and Number of Detected Innervation Zones in the Medial Gastrocnemius Using Multichannel Electromyography

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dc.coverageDOI: 10.4067/S0717-95022023000601775
dc.creatorRodrigo, Guzmán Venegas
dc.creatorFelipe, Palma Traro
dc.creatorJavier, Contreras
dc.creatorCristian, Caparrós Manosalva
dc.date2023
dc.date.accessioned05-01-2026 18:21
dc.date.available05-01-2026 18:21
dc.description<p>The Innervation Zones (IZ) correspond to clusters of neuromuscular junctions. The traditional method of locating IZs through voluntary muscle contractions may not be feasible in individuals with motor disorders. Imposed contractions by electrostimulation are an alternative. However, there is limited evidence regarding the factors that affect inter-evaluator concordance and the number of localized IZs when using imposed contraction. The main objective of this research was to determine the effect of the amplitude of compound motor action potentials (CMAPs) containing the M-wave on inter-evaluator agreement. As a secondary objective, was investigate the effect on the number of detected IZs. Twenty-four healthy volunteers (age: 21.2 ± 1.5years, weight: 67.4 ± 13.2kg, height: 1.68 ± 0.80m) participated in the study. Electrostimulation was applied to the tibial nerve to induce contraction of the medial gastrocnemius. The IZ were identified based on the M-wave recorded through multichannel electromyography. A receiver operating characteristic (ROC) analysis was conducted to assess sensitivity and specificity in detecting the IZs. Inter-rater agreement was evaluated using a two-way mixed effects test to determine the intraclass correlation coefficients (ICC). A p-value less than 0.05 was considered statistically significant. The ROC analysis revealed that for both evaluators, a specificity of 95% was achieved with an amplitude ?30 %. The area under the ROC curve was 0.980 [0.964, 0.996], indicating a strong influence of CMAP amplitude on detection of IZs. The highest level of agreement (ICC = 0.788 [0.713, 0.844]) among the evaluators was observed with CMAP amplitudes equal to or greater than 80 % of the maximum M-wave. The findings of this study demonstrate that both the number and the inter-evaluator concordance for detecting IZs using imposed contractions are strongly influenced by the amplitude of the M-wave. Higher M-wave amplitudes were associated with improved concordance and increased IZ detection, making it crucial to standardize amplitude settings for reliable outcomes.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/da8f39ee-f49b-4af0-90c8-e659c7716e68
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.41 (2023) date: 2023-12-01 nr.6 p.1775-1780
dc.subjectImposed Contraction
dc.subjectInnervation Zones
dc.subjectInter-evaluator concordance
dc.subjectM-wave
dc.subjectMedial Gastrocnemius
dc.titleEffect of M-wave Amplitude on Inter-evaluator Concordance and Number of Detected Innervation Zones in the Medial Gastrocnemius Using Multichannel Electromyographyeng
dc.titleEfecto de la Amplitud de la Onda M sobre la Concordancia entre Evaluadores y el Número de Zonas de Inervación Detectadas en el Gastrocnemio Medial Mediante Electromiografía Multicanalspa
dc.typeArticleeng
dc.typeArtículospa
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