Facultad de Ingeniería y Ciencias Aplicadas

Permanent URI for this community

https://repositorio.uandes.cl/handle/uandes/986

Browse

Browsing Facultad de Ingeniería y Ciencias Aplicadas by Author "Adloor, Sai Darshan"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    33
    (33, 33) Nolasco, Eduardo; Vassiliadis, Vassilios S.; Kähm, Walter; Adloor, Sai Darshan; Ismaili, Riham Al; Conejeros, Raúl; Espaas, Thomas; Gangadharan, Nishanthi; Mappas, Vasileios; Scott, Felipe; Zhang, Qianyue; 33
    Roger W.H. Sargent (1926–2018) was an unprecedented pioneer who foresaw the role that mathematical and computational tools would have in chemical engineering. His visionary work created the multidisciplinary field of Process Systems Engineering (PSE), a field that acts as a central hub influencing all subfields of chemical engineering. His particular interest in optimal control applied to industrial processes led him to develop numerical techniques to solve large-scale optimal control problems. In this work, a brief overview of the theory of optimal control is offered, spanning from its roots in calculus of variations to Pontryagin's maximum principle and some of its extensions. Furthermore, important contributions made by Sargent and his students are presented. Selected applications currently found in literature are presented as well–ranging from classical chemical engineering systems to bioprocesses. Some future perspectives of the field are also presented in the concluding section.
  • Thumbnail Image
    Item
    33
    (33, 33) Silva, Pablo; Scott, Felipe; Adloor, Sai Darshan; Vassiliadis, Vassilios S.; Illanes, Andrés; Wilson, Lorena; Conejeros, Raúl; 33
    Enzyme inactivation significantly impacts reactor performance by reducing substrate conversion and product quality. This study, with its focus on optimizing the economic benefits of a novel two-step biocatalytic system, aims to control biocatalyst replacement intervals and operational conditions, thereby enhancing the economic viability of biocatalytic processes. The results demonstrate that optimal control strategies can be effectively implemented for Continuous Stirred Tank Reactors (CSTRs) and Packed Bed Reactors (PBRs). Moreover, PBRs show distinct advantages due to their enhanced capacity to meet demand, primarily resulting from differences in mixing patterns and the extended contact time between reactants and the biocatalyst. An essential contribution of this work is the detailed spatial analysis of temperature distribution within the PBR, an innovative approach to studying multienzyme systems. Considering a 16-week time horizon, the application of the proposed methodology resulted in a total of 3 catalyst changeovers for the CSTR configuration, and one for the PBR, achieving 80% of the total seasonal demand. Furthermore, the development of a comprehensive model that integrates two-stage enzyme inactivation, diffusional limitations, and Michaelis–Menten kinetics for both enzymes provides a thorough understanding and valuable insights into determining optimal biocatalyst replacement times. This approach advances the design and operation of biocatalytic processes for improved economic performance.