05-01-202605-01-2026<p>In the present work, several mathematical models well-known in the literature for simulating drug release kinetics are compared using available experimental data sets obtained in real systems with different drugs and nano-sized carriers. Herein, the ÷² minimization method, is employedconcluding that the Korsmeyer-Peppas modelprovides the best-ûtin all cases. Hence, (i) better understanding of the exact mass transport mechanism(s) involved in drug(s) release, and (ii) quantitative prediction of the drug release kinetics, can be computed.</p>In the present work, several mathematical models well-known in the literature for simulating drug release kinetics are compared using available experimental data sets obtained in real systems with different drugs and nano-sized carriers. Herein, the ÷2 minimization method, is employedconcluding that the Korsmeyer-Peppas modelprovides the best-ûtin all cases. Hence, (i) better understanding of the exact mass transport mechanism(s) involved in drug(s) release, and (ii) quantitative prediction of the drug release kinetics, can be computed.info:eu-repo/semantics/openAccessDrug dissolutionLeast squares methodMathematical modellingModel comparisonRelease kineticsStatistical analysisDrug dissolutionLeast squares methodMathematical modellingModel comparisonRelease kineticsStatistical analysisArticle