The APOE4 effect: structural brain differences in Alzheimer's disease according to the age at symptom onset

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dc.coverageDOI: 10.1111/ene.15657
dc.creatorForno, Gonzalo
dc.creatorContador, Jose
dc.creatorPérez-Millan, Agnès
dc.creatorGuillen, Nuria
dc.creatorFalgàs, Neus
dc.creatorSarto, Jordi
dc.creatorTort-Merino, Adrià
dc.creatorCastellví, Magdalena
dc.creatorBosch, Beatriz
dc.creatorFernández-Villullas, Guadalupe
dc.creatorBalasa, Mircea
dc.creatorAntonell, Anna
dc.creatorSala- Llonch, Roser
dc.creatorSanchez-Valle, Raquel
dc.creatorHornberger, Michael
dc.creatorLladó, Albert
dc.date2023
dc.date.accessioned2026-01-05T21:17:14Z
dc.date.available2026-01-05T21:17:14Z
dc.description<p>Background and purpose: How the APOE genotype can differentially affect cortical and subcortical memory structures in biomarker-confirmed early-onset (EOAD) and late-onset (LOAD) Alzheimer's disease (AD) was assessed. Method: Eighty-seven cerebrospinal fluid (CSF) biomarker-confirmed AD patients were classified according to their APOE genotype and age at onset. 28 were EOAD APOE4 carriers (+EOAD), 21 EOAD APOE4 non-carriers (–EOAD), 23 LOAD APOE4 carriers (+LOAD) and 15 LOAD APOE4 non-carriers (–LOAD). Grey matter (GM) volume differences were analyzed using voxel-based morphometry in Papez circuit regions. Multiple regression analyses were performed to determine the relation between GM volume loss and cognition. Results: Significantly more mammillary body atrophy in +EOAD compared to –EOAD is reported. The medial temporal and posterior cingulate cortex showed less GM in +LOAD compared to –LOAD. Medial temporal GM volume loss was also found in +EOAD compared to –LOAD. With an exception for +EOAD, medial temporal GM was strongly associated with episodic memory in the three groups, whilst posterior cingulate cortex GM volume was more related with visuospatial abilities. Visuospatial abilities and episodic memory were also associated with the anterior thalamic nucleus in –LOAD. Conclusions: Our results show that the APOE genotype has a significant effect on GM integrity as a function of age of disease onset. Specifically, whilst LOAD APOE4 genotype is mostly associated with increased medial temporal and parietal atrophy compared to –LOAD, for EOAD APOE4 might have a more specific effect on subcortical (mammillary body) structures. The findings suggest that APOE genotype needs to be taken into account when classifying patients by age at onset.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/7629e250-182b-46a9-99bd-602ea9047508
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/67452
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.30 (2023) nr.3 p.597-605
dc.subjectage at symptom onset
dc.subjectAPOE4
dc.subjectearly onset Alzheimer's disease
dc.subjectlate onset Alzheimer's disease
dc.subjectPapez circuit
dc.titleThe APOE4 effect: structural brain differences in Alzheimer's disease according to the age at symptom onseteng
dc.typeArticleeng
dc.typeArtículospa
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