Effect of experimental dentin etchants on dentin bond strength, metalloproteinase inhibition, and antibiofilm activity

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dc.coverageDOI: 10.1016/j.dental.2024.02.017
dc.creatorSahadi, Beatriz Ometto
dc.creatorSebold, Maicon
dc.creatorAndré, Carolina Bosso
dc.creatorNima, Gabriel
dc.creatordos Santos, Andressa
dc.creatorChiari, Marina Damasceno e.Souza de Carvalho
dc.creatorNascimento, Fábio Dupart
dc.creatorTersariol, Ivarne Luis dos Santos
dc.creatorGiannini, Marcelo
dc.date2024
dc.date.accessioned2025-11-18T19:49:38Z
dc.date.available2025-11-18T19:49:38Z
dc.description<p>Objective: this study evaluated dentin microtensile bond strength (µTBS) and failure modes (at 24 h and one year), bonding interface regarding hybridization, surface morphology regarding demineralization, in situ metalloproteinase (MMP) activity, and antibacterial effect of three dentin etchants compared to 35% phosphoric acid (PA). Materials and Methods: The Adper Single Bond 2 adhesive (3 M Oral Care) was applied on moist dentin etched with PA (control) or on air-dried dentin etched with 3% aluminum nitrate + 2% oxalic acid (AN), 6.8% ferric oxalate + 10% citric acid (FO), or 10% citric acid (CA). The µTBS test used 40 human teeth (n = 10). Failure modes and surface morphology were analyzed by scanning electron microscopy (n = 3), while bonding interface morphology and MMP activity were evaluated by laser scanning confocal microscopy (n = 3). Antibacterial activity was evaluated against S. Mutans biofilm by means of viable cells count (CFU/mL). Results: PA presented the highest bond strengths regardless of aging time. PA, AN, and CA showed stable bond strengths after one year of storage. Adhesive and mixed failures were predominant in all groups. Thin hybrid layers with short resin tags were observed for the experimental etchants. The AN-based etchant was able to inhibit MMP activity. All tested etchants presented antibacterial activity against S. Mutans biofilm. Significance: This study suggests different dentin etchants capable of inhibiting MMP activity while also acting as cavity disinfectants.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/f9c687b7-5357-4344-bada-0cd9b0ba29a9
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/56192
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.40 (2024) nr.4 p.e12-e23
dc.subjectAluminum nitrate
dc.subjectAnti-bacterial agents
dc.subjectCitric acid
dc.subjectDental etching
dc.subjectFerric oxalate
dc.subjectMatrix metalloproteinase inhibitors
dc.titleEffect of experimental dentin etchants on dentin bond strength, metalloproteinase inhibition, and antibiofilm activityeng
dc.typeArticleeng
dc.typeArtículospa
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