Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism

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dc.coverageDOI: 10.1038/s41598-024-64228-9
dc.creatorSilva-Pavez, Eduardo
dc.creatorMendoza, Elizabeth
dc.creatorMorgado-Cáceres, Pablo
dc.creatorAhumada-Castro, Ulises
dc.creatorBustos, Galdo
dc.creatorKangme-Encalada, Matías
dc.creatorde Arbina, Amaia Lopez
dc.creatorPuebla-Huerta, Andrea
dc.creatorMuñoz, Felipe
dc.creatorCereceda, Lucas
dc.creatorVaras-Godoy, Manuel
dc.creatorHidalgo, Yessia
dc.creatorCardenas, J. Cesar
dc.date2024
dc.date.accessioned2025-11-18T19:45:11Z
dc.date.available2025-11-18T19:45:11Z
dc.description<p>Increasing evidence supports the hypothesis that cancer progression is under mitochondrial control. Mitochondrial fission plays a pivotal role in the maintenance of cancer cell homeostasis. The inhibition of DRP1, the main regulator of mitochondrial fission, with the mitochondrial division inhibitor (mdivi-1) had been associated with cancer cell sensitivity to chemotherapeutics and decrease proliferation. Here, using breast cancer cells we find that mdivi-1 induces the detachment of the cells, leading to a bulk of floating cells that conserved their viability. Despite a decrease in their proliferative and clonogenic capabilities, these floating cells maintain the capacity to re-adhere upon re-seeding and retain their migratory and invasive potential. Interestingly, the cell detachment induced by mdivi-1 is independent of DRP1 but relies on inhibition of mitochondrial complex I. Furthermore, mdivi-1 induces cell detachment rely on glucose and the pentose phosphate pathway. Our data evidence a novel DRP1-independent effect of mdivi-1 in the attachment of cancer cells. The generation of floating viable cells restricts the use of mdivi-1 as a therapeutic agent and demonstrates that mdivi-1 effect on cancer cells are more complex than anticipated.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/d93e1fce-78d0-41b1-9f87-b71b0eaddcc1
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/53836
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.14 (2024) nr.1
dc.subjectCancer
dc.subjectCell detachment
dc.subjectMdivi-1
dc.subjectMetabolism
dc.subjectMitochondrial complex I
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanismeng
dc.typeArticleeng
dc.typeArtículospa
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