Exploring Neuroprotection against Radiation-Induced Brain Injury: A Review of Key Compounds

Simple item page
dc.coverageDOI: 10.3390/neurosci5040034
dc.creatorGonzález-Johnson, Lucas
dc.creatorFariña, Ariel
dc.creatorFarías, Gonzalo
dc.creatorZomosa, Gustavo
dc.creatorPinilla-González, Víctor
dc.creatorRojas-Solé, Catalina
dc.date2024
dc.date.accessioned2025-11-18T19:46:13Z
dc.date.available2025-11-18T19:46:13Z
dc.descriptionBrain radiation is a crucial tool in neuro-oncology for enhancing local tumor control, but it can lead to mild-to-profound and progressive impairments in cognitive function. Radiation-induced brain injury is a significant adverse effect of radiotherapy for cranioencephalic tumors, primarily caused by indirect cellular damage through the formation of free radicals. This results in late neurotoxicity manifesting as cognitive impairment due to free radical production. The aim of this review is to highlight the role of different substances, such as drugs used in the clinical setting and antioxidants such as ascorbate, in reducing the neurotoxicity associated with radiation-induced brain injury. Currently, there is mainly preclinical and clinical evidence supporting the benefit of these interventions, representing a cost-effective and straightforward neuroprotective strategy.spa
dc.identifierhttps://investigadores.uandes.cl/en/publications/d6242fa7-ea49-4e96-8809-841f3361bdfa
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/54401
dc.languagespa
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.5 (2024) nr.4 p.462-484
dc.titleExploring Neuroprotection against Radiation-Induced Brain Injury: A Review of Key Compoundsspa
dc.typeArticleeng
dc.typeArtículospa
Files
Collections
PURE