A novel Chilean salmon fish backbone-based nanoHydroxyApatite functional biomaterial for potential use in bone tissue engineering

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dc.coverageDOI: 10.3389/fmed.2024.1330482
dc.creatorMuñoz, F.
dc.creatorHaidar, Z. S.
dc.creatorPuigdollers, A.
dc.creatorGuerra, I.
dc.creatorPadilla, M. Cristina
dc.creatorOrtega, N.
dc.creatorGarcía, M. J.
dc.date2024
dc.date.accessioned2026-01-05T21:21:20Z
dc.date.available2026-01-05T21:21:20Z
dc.description<p>Introduction: Given the ensuing increase in bone and periodontal diseases and defects, de novo bone repair and/or regeneration strategies are constantly undergoing-development alongside advances in orthopedic, oro-dental and cranio-maxillo-facial technologies and improvements in bio−/nano-materials. Indeed, there is a remarkably growing need for new oro-dental functional biomaterials that can help recreate soft and hard tissues and restore function and aesthetics of teeth/ dentition and surrounding tissues. In bone tissue engineering, HydroxyApatite minerals (HAp), the most stable CaP/Calcium Phosphate bioceramic and a widely-used material as a bone graft substitute, have been extensively studied for regenerative medicine and dentistry applications, including clinical use. Yet, limitations and challenges owing principally to its bio-mechanical strength, exist and therefore, research and innovation efforts continue to pursue enhancing its bio-effects, particularly at the nano-scale. Methods: Herein, we report on the physico-chemical properties of a novel nanoHydroxyApatite material obtained from the backbone of Salmon fish (patent-pending); an abundant and promising yet under-explored alternative HAp source. Briefly, our nanoS-HAp obtained via a modified and innovative alkaline hydrolysis–calcination process was characterized by X-ray diffraction, electron microscopy, spectroscopy, and a cell viability assay. Results and Discussion: When compared to control HAp (synthetic, human, bovine or porcine), our nanoS-HAp demonstrated attractive characteristics, a promising biomaterial candidate for use in bone tissue engineering, and beyond.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/9b1668d1-2df9-4db8-8fe4-22b39740bc2d
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/69378
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.11 (2024)
dc.subjectbioengineering
dc.subjectbiomaterials
dc.subjecthydroxyapatite
dc.subjectnanotechnology
dc.subjectosteoconduction
dc.subjectosteoinduction
dc.subjectosteointegrative
dc.subjectsalmon bone
dc.subjectSDG 3 - Good Health and Well-being
dc.titleA novel Chilean salmon fish backbone-based nanoHydroxyApatite functional biomaterial for potential use in bone tissue engineeringeng
dc.typeArticleeng
dc.typeArtículospa
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