25 Hydroxy Vitamin D Level, Bone Health, Vitamin D and Calcium Intake in Chilean Patients with Phenylketonuria and Hyperphenylalaninemias
| dc.coverage | DOI: 10.1590/2326-4594-JIEMS-2021-0004 | |
| dc.creator | Leiva, C. | |
| dc.creator | Bravo, P. | |
| dc.creator | Arias, C. | |
| dc.creator | Cabello, J. F. | |
| dc.creator | Leal-Witt, M. J. | |
| dc.creator | Salazar, F. | |
| dc.creator | Cornejo, V. | |
| dc.date | 2021 | |
| dc.date.accessioned | 2025-11-18T19:45:33Z | |
| dc.date.available | 2025-11-18T19:45:33Z | |
| dc.description | <p>It has been shown that there is a decrease in the concentrations of 25 hydroxyvitamin D (25-OHD) and bone mineral density (BMD) in patients with phenylketonuria (PKU) in their follow-up. Our objective was to determine concentrations of 25-OHD in subjects with PKU and hyperphenylalaninemia (HPA). Transversal analytical study considered three groups: G1-PKU with neonatal diagnosis and formula intake without Phe; G2-HPA, without specific treatment and G3-C control group. Sixteen patients per group (aged 6-23) were included. Levels of 25-OHD, lumbar spine (L2-L4), femur and total BMD, intact parathormone (PTH) and vitamin D (VitD) and calcium intake were calculated. The Kruskal-Wallis statistical test was applied (p-value<0,05). Significant differences were detected in concentrations of 25-OHD between G1-PKU and G2-HPA (38.9 ng/mL; 28 ng/mL, respectively) (NV: >30 ng/mL). G1-PKU had a higher intake of VitD, with differences among groups. There were no significant differences among groups in relation to BMD and intact PTH. In conclusion, G1-PKU under treatment and with good adherence, does not present VitD deficiency and no BMD alterations are observed. In contrast, G2-HPA had a lower intake of VitD and decreased 25-OHD concentrations which could affect the bone architecture in the long term. Further studies on the G2-HPA are suggested.</p> | eng |
| dc.identifier | https://investigadores.uandes.cl/en/publications/bd999427-b141-4dc5-b872-6a18013d8bdc | |
| dc.identifier.uri | https://repositorio.uandes.cl/handle/uandes/54028 | |
| dc.language | eng | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | vol.9 (2021) | |
| dc.subject | phenylketonuria | |
| dc.subject | vitamin D and bone mineral density | |
| dc.subject | SDG 3 - Good Health and Well-being | |
| dc.title | 25 Hydroxy Vitamin D Level, Bone Health, Vitamin D and Calcium Intake in Chilean Patients with Phenylketonuria and Hyperphenylalaninemias | eng |
| dc.type | Article | eng |
| dc.type | Artículo | spa |