Evaluación de la sensibilidad y especificidad de la sigmoidoscopia en comparación con la colonoscopia en la detección de actividad inflamatoria intestinal en el seguimiento de pacientes con colitis ulcerosa

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dc.coverageDOI: 10.1016/j.gastrohep.2024.502232
dc.creatorCalderón, Paula
dc.creatorNúñez, Paulina
dc.creatorHerrera, Karin
dc.creatorFlores, Lilian
dc.creatorCórdova, Andrea
dc.creatorCarvajal, Francisca
dc.creatorQuera, Rodrigo
dc.date2025
dc.date.accessioned2025-11-18T19:50:07Z
dc.date.available2025-11-18T19:50:07Z
dc.description<p>Introduction: Ulcerative colitis (UC) is a chronic disease characterized by periods of inflammatory activity and remission, which vary from the rectum to the proximal colon. Currently, mucosal healing is a long-term goal in the management of inflammatory bowel disease, with colonoscopy and sigmoidoscopy being the recommended tools for evaluation. Objective: To assess the effectiveness of both examinations in determining the presence of inflammatory activity in the follow-up of patients with UC. Methods: Retrospective observational study analyzing colonoscopies performed as part of the follow-up of UC patients between January 2021 and July 2023 by gastroenterologists from the Inflammatory Bowel Disease Program at the Clínica Universidad de los Andes. The study compared endoscopic and histological activity observed in the rectosigmoid region with that found in the rest of the colon. Sensitivity and specificity were determined using concordance and correlations tests. Results: A very good concordance and correlation were observed regarding endoscopic findings, with a Kappa index of 0.97 and a Spearman coefficient of 0.97. The Positive Predictive Value (PPV) of sigmoidoscopy for endoscopic activity was 1, and the Negative Predictive Value (NPV) was 0.96. In relation to histological activity, the concordance had a Kappa index of 0.93 and a Spearman coefficient of 0.93, with a PPV of sigmoidoscopy for histological activity being 1 and an NPV of 0.91. Conclusion: This cohort suggests that sigmoidoscopy is a cost-effective option for evaluating mucosal healing in UC patients in symptomatic and biomarker remission. However, complete colonoscopy should be considered in cases of discrepancies with the clinical picture or in colorectal cancer surveillance.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/d9f96733-d9f4-456a-a753-845aa743c094
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/56447
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.48 (2025) nr.3 p.502232
dc.subjectColonoscopy
dc.subjectSigmoidoscopy
dc.subjectUlcerative colitis
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEvaluación de la sensibilidad y especificidad de la sigmoidoscopia en comparación con la colonoscopia en la detección de actividad inflamatoria intestinal en el seguimiento de pacientes con colitis ulcerosaspa
dc.titleEvaluation of the sensitivity and specificity of sigmoidoscopy in comparison to colonoscopy regarding the detection of intestinal inflammatory activity in the follow-up of patients with ulcerative colitiseng
dc.typeArticleeng
dc.typeArtículospa
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