Lipoprotein receptor SR-B1 deficiency enhances adipose tissue inflammation and reduces susceptibility to hepatic steatosis during diet-induced obesity in mice

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dc.coverageDOI: 10.1016/j.bbalip.2021.158909
dc.creatorRivera, Katherine
dc.creatorQuiñones, Verónica
dc.creatorAmigo, Ludwig
dc.creatorSantander, Nicolás
dc.creatorSalas-Pérez, Francisca
dc.creatorXavier, Aline
dc.creatorFernández-Galilea, Marta
dc.creatorCarrasco, Gonzalo
dc.creatorCabrera, Daniel
dc.creatorArrese, Marco
dc.creatorBusso, Dolores
dc.creatorAndia, Marcelo E.
dc.creatorRigotti, Attilio
dc.date2021
dc.date.accessioned2025-11-18T19:40:54Z
dc.date.available2025-11-18T19:40:54Z
dc.description<p>Scavenger receptor class B type 1 (SR-B1) is a membrane lipoprotein receptor/lipid transporter involved in the pathogenesis of atherosclerosis, but its role in obesity and fatty liver development is unclear. Here, we determined the effects of SR-B1 deficiency on plasma metabolic and inflammatory parameters as well as fat deposition in adipose tissue and liver during obesity. To induce obesity, we performed high-fat diet (HFD) exposure for 12 weeks in male SR-B1 knock-out (SR-B1<sup>−/−</sup>, n = 14) and wild-type (WT, n = 12) mice. Compared to HFD-fed WT mice, plasma from HFD-fed SR-B1<sup>−/−</sup> animals exhibited increased total cholesterol, triglycerides (TG) and tumor necrosis factor-α (TNF-α) levels. In addition, hypertrophied adipocytes and macrophage-containing crown-like structures (CLS) were observed in adipose tissue from HFD-fed SR-B1 deficient mice. Remarkably, liver from obese SR-B1<sup>−/−</sup> mice showed attenuated TG content, dysregulation in hepatic peroxisome proliferator-activated receptors (PPARs) expression, increased hepatic TG secretion, and altered hepatic fatty acid (FA) composition. In conclusion, we show that SR-B1 deficiency alters the metabolic environment of obese mice through modulation of liver and adipose tissue lipid accumulation. Our findings provide the basis for further elucidation of SR-B1's role in obesity and fatty liver, two major public health issues that increase the risk of advanced chronic diseases and overall mortality.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/fe5837d3-2be9-43d3-9316-ef8fc71c30a4
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/51524
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.1866 (2021) date: 2021-06-01 nr.6 p.158909
dc.subjectAdipose Tissue/pathology
dc.subjectAnimals
dc.subjectCD36 Antigens/deficiency
dc.subjectDiet, High-Fat/adverse effects
dc.subjectDisease Susceptibility
dc.subjectFatty Acids/metabolism
dc.subjectFatty Liver/complications
dc.subjectInflammation/complications
dc.subjectLiver/metabolism
dc.subjectMale
dc.subjectMice
dc.subjectObesity/complications
dc.subjectTriglycerides/metabolism
dc.subjectSDG 3 - Good Health and Well-being
dc.titleLipoprotein receptor SR-B1 deficiency enhances adipose tissue inflammation and reduces susceptibility to hepatic steatosis during diet-induced obesity in miceeng
dc.typeArticleeng
dc.typeArtículospa
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