Micrornas and their role in the malignant transformation of oral leukoplakia: A scoping review

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dc.coverageDOI: 10.4317/medoral.24975
dc.creatorNiklander, Sven
dc.creatorGuerra, Daniela
dc.creatorContreras, Felipe
dc.creatorGonzález-Arriagada, Wilfredo
dc.creatorMarín, Constanza
dc.date2022
dc.date.accessioned2025-11-18T19:54:22Z
dc.date.available2025-11-18T19:54:22Z
dc.description<p>Background: MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the malignant transformation of oral leukoplakia. Material and Methods: We conducted a systematic search with the following MeSH terms: ‘oral leukoplakia’, ‘carcinoma in situ’, ‘microRNAs’, ‘mouth neoplasms’ and ‘epithelial–mesenchymal transition’ in PubMed/MEDLINE, EMBASE and SpringerLink. Results: Fifteen articles were included for analysis, among which in vivo and in vitro articles were included. A total of 21 different miRNAs were found to be involved in the malignant transformation process of oral leukoplakia. Regarding their possible effects, 6 miRNAs were classified as oncogenic, 5 as tumour suppressors and 10 were related to epithelial–mesenchymal transition, invasion and migration. Conclusions: Based on the current review, we concluded that miRNAs-21, 345, 181-b and 31* seem to be potential markers of malignant transformation of oral leukoplakia. However, further clinical prospective studies are needed in order to validate their utility as prognostic biomarkers.</p>eng
dc.descriptionBackground: MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the malignant transformation of oral leukoplakia. Material and Methods: We conducted a systematic search with the following MeSH terms: ‘oral leukoplakia’, ‘carcinoma in situ’, ‘microRNAs’, ‘mouth neoplasms’ and ‘epithelial–mesenchymal transition’ in PubMed/MEDLINE, EMBASE and SpringerLink. Results: Fifteen articles were included for analysis, among which in vivo and in vitro articles were included. A total of 21 different miRNAs were found to be involved in the malignant transformation process of oral leukoplakia. Regarding their possible effects, 6 miRNAs were classified as oncogenic, 5 as tumour suppressors and 10 were related to epithelial–mesenchymal transition, invasion and migration. Conclusions: Based on the current review, we concluded that miRNAs-21, 345, 181-b and 31* seem to be potential markers of malignant transformation of oral leukoplakia. However, further clinical prospective studies are needed in order to validate their utility as prognostic biomarkers.spa
dc.identifierhttps://investigadores.uandes.cl/en/publications/e6009a34-ce45-45a3-8012-ec81850df325
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/58716
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.27 (2022) date: 2022-01-01 nr.1 p.e77-e84
dc.subjectBiomarkers
dc.subjectMalignant transformation
dc.subjectMiRNAs
dc.subjectOral leukoplakia
dc.subjectOral squamous cell carcinoma
dc.subjectBiomarkers
dc.subjectMalignant transformation
dc.subjectMiRNAs
dc.subjectOral leukoplakia
dc.subjectOral squamous cell carcinoma
dc.titleMicrornas and their role in the malignant transformation of oral leukoplakia: A scoping revieweng
dc.typeArticleeng
dc.typeArtículospa
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