The genetics of bipolar disorder with obesity and type 2 diabetes

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dc.coverageDOI: 10.1016/j.jad.2022.06.084
dc.creatorMiola, Alessandro
dc.creatorDe Filippis, Eleanna
dc.creatorVeldic, Marin
dc.creatorHo, Ada Man Choi
dc.creatorWinham, Stacey J.
dc.creatorMendoza, Mariana
dc.creatorRomo-Nava, Francisco
dc.creatorNunez, Nicolas A.
dc.creatorGardea Resendez, Manuel
dc.creatorPrieto, Miguel L.
dc.creatorMcElroy, Susan L.
dc.creatorBiernacka, Joanna M.
dc.creatorFrye, Mark A.
dc.creatorCuellar-Barboza, Alfredo B.
dc.date2022
dc.date.accessioned2025-11-18T19:48:41Z
dc.date.available2025-11-18T19:48:41Z
dc.description<p>Background: Bipolar disorder (BD) presents with high obesity and type 2 diabetes (T2D) and pathophysiological and phenomenological abnormalities shared with cardiometabolic disorders. Genomic studies may help define if they share genetic liability. This selective review of BD with obesity and T2D will focus on genomic studies, stress their current limitations and guide future steps in developing the field. Methods: We searched electronic databases (PubMed, Scopus) until December 2021 to identify genome-wide association studies, polygenic risk score analyses, and functional genomics of BD accounting for body mass index (BMI), obesity, or T2D. Results: The first genome-wide association studies (GWAS) of BD accounting for obesity found a promising genome-wide association in an intronic gene variant of TCF7L2 that was further replicated. Polygenic risk scores of obesity and T2D have also been associated with BD, yet, no genetic correlations have been demonstrated. Finally, human-induced stem cell studies of the intronic variant in TCF7L2 show a potential biological impact of the products of this genetic variant in BD risk. Limitations: The narrative nature of this review. Conclusions: Findings from BD GWAS accounting for obesity and their functional testing, have prompted potential biological insights. Yet, BD, obesity, and T2D display high phenotypic, genetic, and population-related heterogeneity, limiting our ability to detect genetic associations. Further studies should refine cardiometabolic phenotypes, test gene-environmental interactions and add population diversity.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/2ddaa65d-5224-4030-91d5-98151222e52a
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55699
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.313 (2022) date: 2022-09-15 p.222-231
dc.subjectBipolar disorder
dc.subjectDiabetes type 2
dc.subjectGenome-wide association study
dc.subjectGenomics
dc.subjectObesity
dc.subjectPolygenic risk score
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe genetics of bipolar disorder with obesity and type 2 diabeteseng
dc.typeReview articleeng
dc.typeArtículo de revisiónspa
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