Anatase incorporation to bioactive scaffolds based on salmon gelatin and its effects on muscle cell growth

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dc.coverageDOI: 10.3390/POLYM12091943
dc.creatorAcevedo, Cristian A.
dc.creatorOlguín, Yusser
dc.creatorOrellana, Nicole
dc.creatorSánchez, Elizabeth
dc.creatorPepczynska, Marzena
dc.creatorEnrione, Javier
dc.date2020
dc.date.accessioned2025-11-18T19:47:09Z
dc.date.available2025-11-18T19:47:09Z
dc.description<p>The development of new polymer scaffolds is essential for tissue engineering and for culturing cells. The use of non-mammalian bioactive components to formulate these materials is an emerging field. In our previous work, a scaffold based on salmon gelatin was developed and tested in animal models to regenerate tissues effectively and safely. Here, the incorporation of anatase nanoparticles into this scaffold was formulated, studying the new composite structure by scanning electron microscopy, differential scanning calorimetry and dynamic mechanical analysis. The incorporation of anatase nanoparticles modified the scaffold microstructure by increasing the pore size from 208 to 239 μm and significantly changing the pore shape. The glass transition temperature changed from 46.9 to 55.8 °C, and an increase in the elastic modulus from 79.5 to 537.8 kPa was observed. The biocompatibility of the scaffolds was tested using C2C12 myoblasts, modulating their attachment and growth. The anatase nanoparticles modified the stiffness of the material, making it possible to increase the growth of myoblasts cultured onto scaffolds, which envisions their use in muscle tissue engineering.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/a1e0aabf-83fc-4ebf-b095-e48e1cf7cdc5
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/54889
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.12 (2020) date: 2020-08-28 nr.9 p.1-11
dc.subjectAnatase
dc.subjectMuscle cells
dc.subjectSalmon gelatin
dc.subjectScaffold
dc.subjectTissue engineering
dc.titleAnatase incorporation to bioactive scaffolds based on salmon gelatin and its effects on muscle cell growtheng
dc.typeArticleeng
dc.typeArtículospa
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