Clinical Overview of Psoriasis and Psoriatic Arthritis

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dc.coverageDOI: 10.1007/978-3-031-08736-3_19
dc.creatorValenzuela, Fernando
dc.creatorFlores, Rodrigo
dc.date2022
dc.date.accessioned2026-01-05T21:10:47Z
dc.date.available2026-01-05T21:10:47Z
dc.description<p>Psoriasis is a chronic and immune-mediated inflammatory disease affecting the skin and joints of approximately 2-3% of the world population, with a bimodal age distribution, compromising both sexes equally. Its cause is complex and not completely clarified; there would be genetic susceptibility on which triggering environmental factors would lead to a dysregulated inflammatory response, alterations in the skin barrier functions, and immune response that have a systemic impact, determining the appearance or progression of comorbidities. Psoriasis presents a large clinical polymorphism and a highly variable degree of individual involvement; its diagnosis is based almost entirely on its clinical characteristics and rarely requires histological confirmation. The choice of long-term therapy is determined by the severity of the disease, comorbidities, special locations, failure to previous treatments, and access to medical care. Lately, biological therapy has meant a great leap in effectiveness, even achieving complete disease resolution.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/42805795-62c9-4560-a25f-19d2417dc56f
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/64517
dc.languageeng
dc.publisherSpringer International Publishing
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourceTextbook of Dermatologic Ultrasound, p.345-365. Springer International Publishing. [ISBN 9783031087356]
dc.subjectBiological
dc.subjectComorbidities
dc.subjectImmune-mediated
dc.subjectInflammation
dc.subjectPsoriasis
dc.subjectPsoriatic arthritis
dc.subjectSystemic
dc.titleClinical Overview of Psoriasis and Psoriatic Arthritiseng
dc.typeChaptereng
dc.typeCapítulospa
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