Clinical significance of Bacteroides fragilis as a potential prognostic factor in colorectal cancer

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dc.coverageDOI: 10.1016/j.anaerobe.2023.102784
dc.creatorMatsumiya, Yuriko
dc.creatorSuenaga, Mitsukuni
dc.creatorIshikawa, Toshiaki
dc.creatorKudo, Toshifumi
dc.creatorNakagawa, Tsuyoshi
dc.creatorOkamoto, Kentaro
dc.creatorTokunaga, Masanori
dc.creatorHurtado, Claudia
dc.creatorYamada, Yuki
dc.creatorOka, Kentaro
dc.creatorTakahashi, Motomichi
dc.creatorLopez Kostner, Luis Francisco
dc.creatorO'Ryan Gallardo, Miguel Luis
dc.creatorUetake, Hiroyuki
dc.creatorKinugasa, Yusuke
dc.date2023
dc.date.accessioned2025-11-18T19:45:58Z
dc.date.available2025-11-18T19:45:58Z
dc.description<p>Introduction: Bacteroides fragilis (B. fragilis) is considered to act in an anti-inflammatory manner on the intestinal tract. On the contrary, enterotoxigenic B. fragilis (ETBF), a subtype of B. fragilis, produces an enterotoxin (BFT; B. fragilis toxin), leading to asymptomatic chronic infections and colonic tumor formation. However, the impact of B. fragilis and ETBF on the clinical outcome of colorectal cancer (CRC) remains unclear. We aim to assess whether their presence affects the outcome in patients with CRC after curative resection. Methods: We obtained 197 pairs of matched formalin-fixed paraffin-embedded samples from cancerous and adjacent non-cancerous tissues of patients with pathological stage (pstage) II and III CRC after curative resection. The presence of B. fragilis and ETBF were estimated using real-time polymerase chain reaction, and recurrence-free survival (RFS) and overall survival (OS) of the patients were analyzed. Results: 16 S rRNA for B. fragilis and bft DNA were detected in 120 (60.9%) and 12 (6.1%) of the 197 patients, respectively. B. fragilis-positive patients had better RFS than B. fragilis-negative patients, although that was not statistically significant. In subgroup analysis, better outcomes on RFS were observed in the presence of B. fragilis in pstage II and left-sided CRC. The association of B. fragilis positivity on OS was accentuated in the depth of T4 subgroup. No significant differences were observed in RFS and OS between ETBF and non-toxigenic B. fragilis. Conclusions: Our findings suggest that the presence of B. fragilis is associated with better outcomes in patients with pstage II and III CRC after curative resection.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/69a82037-69a4-4d26-a636-07be0910956b
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/54255
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.84 (2023)
dc.subjectBacterial DNA
dc.subjectBacteroides fragilis
dc.subjectColorectal cancer
dc.subjectPathogenic biology
dc.subjectReal-time polymerase chain reaction
dc.subjectSDG 3 - Good Health and Well-being
dc.titleClinical significance of Bacteroides fragilis as a potential prognostic factor in colorectal cancereng
dc.typeArticleeng
dc.typeArtículospa
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