Contribution of tryptophan and its metabolites to transplant outcome: a mini-review

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dc.coverageDOI: 10.3389/fimmu.2024.1395421
dc.creatorDonoso-Meneses, Darío
dc.creatorPadilla, Cristina
dc.creatorMoya-Guzmán, María José
dc.creatorAlegre, Maria Luisa
dc.creatorPino-Lagos, Karina
dc.date2024
dc.date.accessioned2025-11-18T19:43:51Z
dc.date.available2025-11-18T19:43:51Z
dc.description<p>Long-term tolerance in the absence of immunosuppressive drugs is a major goal in the transplantation field, not yet attained. Recent research on the role of commensal microbiota in the control of immunity has opened new avenues for the search of novel clinical interventions. Indeed, products of intestinal metabolism generated by both host cells and the microbiota have been identified as modulators of the immune response. Among these, tryptophan (Trp) and its derivatives are being investigated to understand their impact on alloimmunity and their potential usefulness as therapeutic targets to improve allograft survival. Here, we reviewed the latest findings on the contribution of Trp metabolic pathways to transplant outcomes.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/025474d9-88ee-442e-81f5-2701ff440695
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/53105
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.15 (2024) p.1395421
dc.subjectimmune regulation
dc.subjectmicrobiota
dc.subjecttolerance
dc.subjecttransplantation
dc.subjecttrypthophan metabolism
dc.titleContribution of tryptophan and its metabolites to transplant outcome: a mini-revieweng
dc.typeShort surveyeng
dc.typeEstudio brevespa
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