Regenerative potential of leucocyte- and platelet-rich fibrin.: Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis

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dc.coverageDOI: 10.1111/jcpe.12643
dc.creatorCastro, Ana B.
dc.creatorMeschi, Nastaran
dc.creatorTemmerman, Andy
dc.creatorPinto, Nelson
dc.creatorLambrechts, Paul
dc.creatorTeughels, Wim
dc.creatorQuirynen, Marc
dc.date2017
dc.date.accessioned2025-11-18T19:47:25Z
dc.date.available2025-11-18T19:47:25Z
dc.description<p>Aim: To analyse the regenerative potential of leucocyte- and platelet-rich fibrin (L-PRF) during periodontal surgery. Materials and Methods: An electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow-up limitation was applied. Pocket depth (PD), clinical attachment level (CAL), bone fill, keratinized tissue width (KTW), recession reduction and root coverage (%) were considered as outcome. When possible, meta-analysis was performed. Results: Twenty-four articles fulfilled the inclusion and exclusion criteria. Three subgroups were created: intra-bony defects (IBDs), furcation defects and periodontal plastic surgery. Meta-analysis was performed in all the subgroups. Significant PD reduction (1.1 ± 0.5 mm, p &lt; 0.001), CAL gain (1.2 ± 0.6 mm, p &lt; 0.001) and bone fill (1.7 ± 0.7 mm, p &lt; 0.001) were found when comparing L-PRF to open flap debridement (OFD) in IBDs. For furcation defects, significant PD reduction (1.9 ± 1.5 mm, p = 0.01), CAL gain (1.3 ± 0.4 mm, p &lt; 0.001) and bone fill (1.5 ± 0.3 mm, p &lt; 0.001) were reported when comparing L-PRF to OFD. When L-PRF was compared to a connective tissue graft, similar outcomes were recorded for PD reduction (0.2 ± 0.3 mm, p &gt; 0.05), CAL gain (0.2 ± 0.5 mm, p &gt; 0.05), KTW (0.3 ± 0.4 mm, p &gt; 0.05) and recession reduction (0.2 ± 0.3 mm, p &gt; 0.05). Conclusions: L-PRF enhances periodontal wound healing.</p>eng
dc.descriptionAim<br/>To analyse the regenerative potential of leucocyte- and platelet-rich fibrin (L-PRF) during periodontal surgery.<br/>Materials and Methods<br/>An electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow-up limitation was applied. Pocket depth (PD), clinical attachment level (CAL), bone fill, keratinized tissue width (KTW), recession reduction and root coverage (%) were considered as outcome. When possible, meta-analysis was performed.<br/>Results<br/>Twenty-four articles fulfilled the inclusion and exclusion criteria. Three subgroups were created: intra-bony defects (IBDs), furcation defects and periodontal plastic surgery. Meta-analysis was performed in all the subgroups. Significant PD reduction (1.1 ± 0.5 mm, p &lt; 0.001), CAL gain (1.2 ± 0.6 mm, p &lt; 0.001) and bone fill (1.7 ± 0.7 mm, p &lt; 0.001) were found when comparing L-PRF to open flap debridement (OFD) in IBDs. For furcation defects, significant PD reduction (1.9 ± 1.5 mm, p = 0.01), CAL gain (1.3 ± 0.4 mm, p &lt; 0.001) and bone fill (1.5 ± 0.3 mm, p &lt; 0.001) were reported when comparing L-PRF to OFD. When L-PRF was compared to a connective tissue graft, similar outcomes were recorded for PD reduction (0.2 ± 0.3 mm, p &gt; 0.05), CAL gain (0.2 ± 0.5 mm, p &gt; 0.05), KTW (0.3 ± 0.4 mm, p &gt; 0.05) and recession reduction (0.2 ± 0.3 mm, p &gt; 0.05).<br/>Conclusions<br/>L-PRF enhances periodontal wound healing.spa
dc.identifierhttps://investigadores.uandes.cl/en/publications/1e5ad6ea-18cf-49c1-b6af-65637f484af3
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55022
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.44 (2017) date: 2017-01-01 nr.1 p.67-82
dc.subjectbone regeneration
dc.subjectgingival recession
dc.subjectintra-bony defects
dc.subjectleucocyte–platelet-rich fibrin
dc.subjectopen flap debridement
dc.subjectplatelet-rich fibrin
dc.subjecttissue regeneration
dc.subjectBone Regeneration
dc.subjectgingivalrecession
dc.subjectintra-bony defects
dc.subjecteucocyte–platelet-rich fibrin
dc.subjectopen flap debridement
dc.subjectplatelet-rich fibrin
dc.subjectTissue regeneration
dc.titleRegenerative potential of leucocyte- and platelet-rich fibrin.: Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysiseng
dc.typeReview articleeng
dc.typeArtículo de revisiónspa
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