Estrategias para la prevención primaria y secundaria del cáncer gástrico: consenso chileno de panel de expertos con técnica Delfi

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dc.coverageDOI: 10.1016/j.gastrohep.2024.01.008
dc.creatorCorsi Sotelo, Óscar
dc.creatorPizarro Rojas, Margarita
dc.creatorRollán Rodríguez, Antonio
dc.creatorSilva Figueroa, Verónica
dc.creatorAraya Jofré, Raúl
dc.creatorBufadel Godoy, María Ester
dc.creatorCortés González, Pablo
dc.creatorGonzález Donoso, Robinson
dc.creatorFuentes López, Eduardo
dc.creatorLatorre Selvat, Gonzalo
dc.creatorMedel-Jara, Patricio
dc.creatorReyes Placencia, Diego
dc.creatorPizarro Véliz, Mauricio
dc.creatorGarchitorena Marqués, María Jesús
dc.creatorZegers Vial, María Trinidad
dc.creatorCrispi Galleguillos, Francisca
dc.creatorEspinoza, Manuel A.
dc.creatorRiquelme Pérez, Arnoldo
dc.date2024
dc.date.accessioned2025-11-18T19:52:43Z
dc.date.available2025-11-18T19:52:43Z
dc.description<p>Introduction: Gastric cancer (GC) is the first cause of cancer-related death in Chile and 6<sup>th</sup> in Latin America and the Caribbean (LAC). Helicobacter pylori (H. pylori) is the main gastric carcinogen, and its treatment reduces GC incidence and mortality. Esophageal-gastro-duodenoscopy (EGD) allows for the detection of premalignant conditions and early-stage GC. Mass screening programs for H. pylori infection and screening for premalignant conditions and early-stage GC are not currently implemented in LAC. The aim of this study is to establish recommendations for primary and secondary prevention of GC in asymptomatic standard-risk populations in Chile. Methods: Two on-line synchronous workshops and a seminar were conducted with Chilean experts. A Delphi panel consensus was conducted over 2 rounds to achieve &gt;80% agreement on proposed primary and secondary prevention strategies for the population stratified by age groups. Results: 10, 12, and 12 experts participated in two workshops and a seminar, respectively. In the Delphi panel, 25 out of 37 experts (77.14%) and 28 out of 52 experts (53.85%) responded. For the population aged 16-34, there was no consensus on non-invasive testing and treatment for H. pylori, and the use of EGD was excluded. For the 35-44 age group, non-invasive testing and treatment for H. pylori is recommended, followed by subsequent test-of-cure using non-invasive tests (stool antigen test or urea breath test). In the ≥45 age group, a combined strategy is recommended, involving H. pylori testing and treatment plus non-invasive biomarkers (H. pylori IgG serology and serum pepsinogens I and II); subsequently, a selected group of subjects will undergo EGD with gastric biopsies (Sydney Protocol), which will be used to stratify surveillance according to the classification Operative Link for Gastritis Assessment (OLGA); every 3 years for OLGA III-IV and every 5 years for OLGA I-II. Conclusion: A “test-and-treat” strategy for H. pylori infection based on non-invasive studies (primary prevention) is proposed in the 35-44 age group, and a combined strategy (serology and EGD) is recommended for the ≥45 age group (primary and secondary prevention). These strategies are potentially applicable to other countries in LAC.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/0e2ea9b6-ab70-4b75-8bd7-a31ad370ebbb
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/57861
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.47 (2024) nr.8 p.845-857
dc.subjectChile
dc.subjectEarly detection of cancer
dc.subjectEndoscopy
dc.subjectGastrointestinal
dc.subjectHelicobacter pylori
dc.subjectPrimary prevention
dc.subjectStomach neoplasms
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEstrategias para la prevención primaria y secundaria del cáncer gástrico: consenso chileno de panel de expertos con técnica Delfispa
dc.titleChilean consensus by expert panel using the Delphi technique for primary and secondary prevention of gastric cancereng
dc.typeArticleeng
dc.typeArtículospa
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