An Innovative Regenerative Endodontic Procedure Using Leukocyte and Platelet-rich Fibrin Associated with Apical Surgery: A Case Report

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dc.coverageDOI: 10.1016/j.joen.2017.07.002
dc.creatorPinto, Nelson
dc.creatorHarnish, Alexandra
dc.creatorCabrera, Carolina
dc.creatorAndrade, Catherine
dc.creatorDruttman, Tony
dc.creatorBrizuela, Claudia
dc.date2017
dc.date.accessioned2025-11-18T19:47:17Z
dc.date.available2025-11-18T19:47:17Z
dc.description<p>Regenerative endodontic procedures (REPs) associated with apical surgery could represent an alternative treatment strategy for patients whose teeth present incomplete root formation and extensive apical lesions. Leukocyte platelet-rich fibrin (L-PRF) has potential benefits in REPs; it could promote apical root formation and optimal bone healing. The aim of this case report was to describe innovative regenerative endodontic therapy using L-PRF in the root canal and an extensive apical lesion in an immature tooth with dens invaginatus and asymptomatic apical periodontitis. A healthy 20-year-old woman was referred to the dental clinic of the Universidad de Los Andes, Santiago, Chile, for endodontic treatment in tooth # 22 with incomplete root development and an extensive apical lesion. The diagnosis was asymptomatic apical periodontitis associated with dens invaginatus type II. The patient was treated with an innovative approach using L-PRF in REPs associated with apical surgery. Follow-ups were performed at 6 months and 1 year later. They included periapical radiographs, cone-beam computed tomographic imaging, sensitivity, and vitality tests. The clinical evaluations performed at 6 months and 1 year revealed an absence of symptoms. The radiographic evaluations showed that the apical lesion was resolved. The cone-beam images indicated that the root length increased and the walls had thickened. The sensitivity tests were positive, and the laser Doppler flowmetry showed positive blood flow after 1 year. The success of the results in this case report indicate that L-PRF can be used as a complement in apical surgery and REPs and could provide an innovative alternative treatment strategy for complex clinical cases like these.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/5b47153c-b923-4e35-b34b-77d67ca1bc71
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/54958
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.43 (2017) nr.11 p.1828-1834
dc.subjectDens in dente
dc.subjectendodontics
dc.subjectguided tissue regeneration
dc.subjectplatelet-rich plasma
dc.titleAn Innovative Regenerative Endodontic Procedure Using Leukocyte and Platelet-rich Fibrin Associated with Apical Surgery: A Case Reporteng
dc.typeArticleeng
dc.typeArtículospa
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