Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis

Simple item page
dc.coverageDOI: 10.3390/nu13051704
dc.creatorSerra, Ramón
dc.creatorPeñailillo, Reyna
dc.creatorMonteiro, Lara
dc.creatorMonckeberg, Max
dc.creatorPeña, Macarena
dc.creatorMoyano, Lía
dc.creatorBrunner, Camila
dc.creatorVega, Georgina
dc.creatorChoolani, Mahesh
dc.creatorIllanes, Sebastián
dc.date2021
dc.date.accessioned2025-11-18T19:54:00Z
dc.date.available2025-11-18T19:54:00Z
dc.description<p>Preterm birth (PTB) is a major cause of neonatal death and long-term consequences for the newborn. This review aims to update the evidence about the potential benefit of pharmacological supplementation with omega 3 fatty acids during pregnancy on the incidence of PTB. The Medline, Embase, Cochrane Library and Central databases were searched until 28 June 2020 for RCTs in which omega 3 supplementation was used versus placebo to reduce PTB risk. Data from 37 trials were analyzed. We found an 11% reduction in PTB risk (RR(risk ratios), 0.89; 95% CI (confidence intervals), 0.82 to 0.97) in trials using omega 3 supplements versus placebo. Regarding early PTB (ePTB), there was a 27% reduction in the risk of ePTB (RR, 0.73; 95% CI, 0.58 to 0.92). However, after sensitivity analyses, there were no significant differences in PTB and ePTB risk (PTB RR, 0.92; 95% CI, 0.83 to 1.01, ePTB RR, 0.82; 95% CI, 0.61 to 1.09). We conclude that omega 3 supplementation during pregnancy does not reduce the risk of PTB and ePTB. More studies are required to determine the effect of omega 3 supplementations during pregnancy and the risk of detrimental fetal outcomes.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/d96dc884-485f-4807-b998-ca373b50c3c7
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/58525
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.13 (2021) date: 2021-05-18 nr.5
dc.subjectMeta-analysis
dc.subjectOmega 3 supplementation
dc.subjectPreterm birth
dc.titleSupplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysiseng
dc.typeArticleeng
dc.typeArtículospa
Files
Collections
PURE