Clinical characterization of patients with bipolar disorder and a history of asthma: An exploratory study

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dc.coverageDOI: 10.1016/j.jpsychires.2023.05.061
dc.creatorRomo-Nava, Francisco
dc.creatorBlom, Thomas
dc.creatorCuellar-Barboza, Alfredo B.
dc.creatorBarrera, Francisco J.
dc.creatorMiola, Alessandro
dc.creatorMori, Nicole N.
dc.creatorPrieto, Miguel L.
dc.creatorVeldic, Marin
dc.creatorSingh, Balwinder
dc.creatorGardea-Resendez, Manuel
dc.creatorNunez, Nicolas A.
dc.creatorOzerdem, Aysegul
dc.creatorBiernacka, Joanna M.
dc.creatorFrye, Mark A.
dc.creatorMcElroy, Susan L.
dc.date2023
dc.date.accessioned2025-11-18T19:49:15Z
dc.date.available2025-11-18T19:49:15Z
dc.description<p>Introduction: Bipolar disorder (BD) and asthma are leading causes of morbidity in the US and frequently co-occur. Objectives: We evaluated the clinical features and comorbidities of patients with BD and a history of asthma. Methods: In a cross-sectional analysis from the Mayo Clinic Bipolar Biobank, we explored the clinical characteristics of the BD and an asthma phenotype and fitted a multivariable regression model to identify risk factors for asthma. Results: A total of 721 individuals with BD were included. From these, 140 (19%) had a history of asthma. In a multivariable model only sex and evening chronotype were significant predictors of asthma with the odds ratios and 95% confidence intervals being 1.65 (1.00, 2.72; p=0.05) and 1.99 (1.25, 3.17; p &lt; 0.01), respectively. Individuals with asthma had higher odds of having other medical comorbidities after adjusting for age, sex, and site including hypertension (OR = 2.29 (95% CI 1.42, 3.71); p &lt; 0.01), fibromyalgia (2.29 (1.16, 4.51); p=0.02), obstructive sleep apnea (2.03 (1.18, 3.50); p=0.01), migraine (1.98 (1.31, 3.00); p &lt; 0.01), osteoarthritis (2.08 (1.20, 3.61); p &lt; 0.01), and COPD (2.80 (1.14, 6.84); p=0.02). Finally, individuals currently on lithium were less likely to have a history of asthma (0.48 (0.32, 0.71); p &lt; 0.01). Conclusion: A history of asthma is common among patients with BD and is associated with being female and having an evening chronotype, as well as with increased odds of having other medical comorbidities. A lower likelihood of a history of asthma among those currently on lithium is an intriguing finding with potential clinical implications that warrants further study.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/76415fc2-2758-4f95-afe0-68e3cb11d0c4
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55996
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.164 (2023) p.8-14
dc.subjectAsthma
dc.subjectBipolar disorder
dc.subjectChronotype
dc.subjectComorbid
dc.subjectFibromyalgia
dc.subjectHypertension
dc.subjectLithium
dc.subjectMigraine
dc.subjectOsteoarthritis
dc.subjectSleep apnea
dc.subjectSDG 3 - Good Health and Well-being
dc.titleClinical characterization of patients with bipolar disorder and a history of asthma: An exploratory studyeng
dc.typeArticleeng
dc.typeArtículospa
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