Physicochemical characterization of chitosan-hyaluronan-coated solid lipid nanoparticles for the targeted delivery of paclitaxel: A proof-of-concept study in breast cancer cells

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dc.coverageDOI: 10.2217/nnm-2016-0371
dc.creatorCampos, Javier
dc.creatorHaidar, Ziyad Samir
dc.date2017
dc.date.accessioned2025-11-18T19:40:10Z
dc.date.available2025-11-18T19:40:10Z
dc.descriptionAim: To investigate the potential of modified solid lipid nanoparticles (SLN) for the delivery of paclitaxel (PAX). Materials & methods: SLN loaded with PAX were prepared via modified high-pressure hot homogenization. Formulation parameters were optimized to obtain a high-quality delivery system. SLN cores were coated, layer-by-layer, with a chitosan and hyaluronan (HA) shell. Selectivity toward HA receptors was tested in a breast cancer cell line, MCF-7. Results: Stable and reproducible nano-sized and negatively charged nanoparticles resulted. Findings reveal that chitosan-HA-coated SLN facilitated the targeting, cellular uptake and the time-/dose-controlled delivery and release of PAX, enhancing intrinsic chemotherapeutic activities. Conclusion: SLN are suitable carrier candidates for nano-oncology given their localized, and potent cytotoxic potential overcoming multidrug-resistant cancer cells.eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/ed20afb5-e2bb-45f6-86a1-afa310a14e74
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/51149
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.12 (2017) date: 2017-03-01 nr.5 p.473-490
dc.subjectchitosan
dc.subjectdrug delivery
dc.subjecthyaluronan
dc.subjectlayer-by-layer
dc.subjectmultidrug resistance
dc.subjectnanoncology
dc.subjectpaclitaxel
dc.subjectsolid lipid nanoparticles
dc.subjectchitosan
dc.subjectdrug delivery
dc.subjecthyaluronan
dc.subjectlayer-by-layer
dc.subjectmultidrug resistance
dc.subjectnanoncology
dc.subjectpaclitaxel
dc.subjectsolid lipid nanoparticles
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePhysicochemical characterization of chitosan-hyaluronan-coated solid lipid nanoparticles for the targeted delivery of paclitaxel: A proof-of-concept study in breast cancer cellseng
dc.typeArticleeng
dc.typeArtículospa
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