Relationship between aggressive features of oral squamous cell carcinoma and the immunoexpression of CX3CR1, CX3CL1 and ITGAV

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dc.coverageDOI: 10.1016/j.oooo.2024.04.002
dc.creatorMartínez-Flores, René
dc.creatorLozano-Burgos, Carlo
dc.creatorNiklander, Sven Eric
dc.creatorFernández-Cuya, Michelle
dc.creatorLopes, Márcio Ajudarte
dc.creatorGonzález-Arriagada, Wilfredo Alejandro
dc.date2024
dc.date.accessioned2025-11-18T19:49:55Z
dc.date.available2025-11-18T19:49:55Z
dc.description<p>OBJECTIVE: We aimed to describe the association between CX3CR1, CX3CL1, and ITGAV immunoexpression with PNI and adverse oncologic outcomes in patients with OSCC.</p><p>STUDY DESIGN: Expression CX3CR1, CX3CL1, and ITGAV was assessed by immunohistochemistry in a cohort of 50 paraffin-embedded resections of OSCC. Survival analysis, Cox, and binary logistic regressions were undertaken to determine the impact on patient survival and predictive value for PNI.</p><p>RESULTS: CX3CL1 positive nerves exhibited a significant association with tumor budding (TB) (P = .043), whereas nerves positive for ITGAV were associated with PNI (P = .021), T3-T4 tumor size (P = .029), and III-IV stage (P = .044). Cases with ITGAV-positive nerves exhibited an odds ratio of 9.603 (P = .008) for PNI, whereas cases with CX3CL1-positive nerves exhibited and odds ratio of 4.682 (P = .033) for TB. A trend toward decreased 5-year overall survival (P = .078) and 5-year disease-specific survival (P = .09) was observed in relation to ITGAV-positive nerves. However, no independent predictors for poor survival were identified.</p><p>CONCLUSIONS: The expression of ITGAV was associated with PNI and advanced disease, whereas the expression of CX3CL1 was related to TB, suggesting that ITGAV and CX3CL1 are involved in their respective developments. Therefore, further investigations are encouraged to assess the potential utility of targeted therapies against CX3CL1 receptors in OSCC.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/c169395e-69c7-4d28-bd64-9cc9d0fca371
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/56334
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.138 (2024) date: 2024-07-01 nr.1 p.79-87
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBiomarkers, Tumor/metabolism
dc.subjectCX3C Chemokine Receptor 1/metabolism
dc.subjectCarcinoma, Squamous Cell/metabolism
dc.subjectChemokine CX3CL1/metabolism
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMouth Neoplasms/pathology
dc.subjectNeoplasm Invasiveness
dc.subjectNeoplasm Staging
dc.subjectPredictive Value of Tests
dc.subjectPrognosis
dc.subjectSurvival Analysis
dc.titleRelationship between aggressive features of oral squamous cell carcinoma and the immunoexpression of CX3CR1, CX3CL1 and ITGAVeng
dc.typeArticleeng
dc.typeArtículospa
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