Micro-arranged ZnO particles and conductive fillers in PCL composites for enhanced piezoelectric and dielectric properties in bone tissue engineering applications

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dc.coverageDOI: 10.1016/j.matdes.2025.113672
dc.creatorFernández-Gil, Francisco
dc.creatorOlate-Moya, Felipe
dc.creatorAguilar-Cosme, José Ricardo
dc.creatorGarcía-Molleja, Javier
dc.creatorFernández-Blázquez, Juan Pedro
dc.creatorCartmell, Sarah
dc.creatorPalza, Humberto
dc.date2025
dc.date.accessioned05-01-2026 18:23
dc.date.available05-01-2026 18:23
dc.description<p>Piezoelectric polymers are promising for replicating bone tissue's piezoelectric properties. Typically, non-piezoelectric biopolymers are combined with piezoelectric particles, but this yields low piezoelectric output. We addressed this by aligning piezoelectric zinc oxide (ZnO) micro-rods in 3D-printed polycaprolactone (PCL) scaffolds and adding conductive particles like thermally reduced graphene oxide (TrGO). Our findings revealed that controlled particle alignment in PCL/ZnO composites significantly enhanced dielectric properties. TrGO further improved these properties by creating conductive pathways and micro-capacitor networks by apparent polarization due to electron displacement, promoting Maxwell-Wagner-Sillars effect. This design strategy significantly increased dielectric and piezoelectric performance, achieving values akin to bone tissue. TrGO also boosted the piezoelectric response, with maximum voltage generation of 696 ± 52 and 142 ± 9 mV during direct contact mechanical pressure by a linear actuator and remote mechanical pressure induced by ultrasound waves, respectively. The 3D-printed composites demonstrated bioactivity for MC3T3-E1, enhanced ALP activity, improved cell adhesion, migration, and extracellular matrix formation under remote ultrasound stimulation, underscoring the potential of these novel ternary composites for bone tissue engineering.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/31ab76df-87d6-4de5-8fea-8629f5af829b
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.251 (2025)
dc.subject3D-printing
dc.subjectInterfacial polarization
dc.subjectParticle alignment
dc.subjectPiezoelectricity
dc.subjectScaffold
dc.subjectUltrasound
dc.titleMicro-arranged ZnO particles and conductive fillers in PCL composites for enhanced piezoelectric and dielectric properties in bone tissue engineering applicationseng
dc.typeArticleeng
dc.typeArtículospa
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