Revisiting the bipolar disorder with migraine phenotype: Clinical features and comorbidity

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dc.coverageDOI: 10.1016/j.jad.2021.08.026
dc.creatorRomo-Nava, Francisco
dc.creatorBlom, Thomas
dc.creatorCuellar-Barboza, Alfredo B.
dc.creatorAwosika, Oluwole O.
dc.creatorMartens, Brian E.
dc.creatorMori, Nicole N.
dc.creatorColby, Colin L.
dc.creatorPrieto, Miguel L.
dc.creatorVeldic, Marin
dc.creatorSingh, Balwinder
dc.creatorGardea-Resendez, Manuel
dc.creatorNunez, Nicolas A.
dc.creatorOzerdem, Aysegul
dc.creatorBiernacka, Joanna M.
dc.creatorFrye, Mark A.
dc.creatorMcElroy, Susan L.
dc.date2021
dc.date.accessioned2025-11-18T19:41:26Z
dc.date.available2025-11-18T19:41:26Z
dc.description<p>Introduction: To evaluate the prevalence and clinical correlates of lifetime migraine among patients with bipolar disorder (BD). Methods: In a cross-sectional study, we evaluated 721 adults with BD from the Mayo Clinic Bipolar Disorder Biobank and compared clinical correlates of those with and without a lifetime history of migraine. A structured clinical interview (DSM-IV) and a clinician-assessed questionnaire were utilized to establish a BD diagnosis, lifetime history of migraine, and clinical correlates. Results: Two hundred and seven (29%) BD patients had a lifetime history of migraine. BD patients with migraine were younger and more likely to be female as compared to those without migraine (p values &lt;0.01). In a multivariate logistic regression model, younger age (OR=0.98, p&lt;0.01), female sex (OR=2.02, p&lt;0.01), higher shape/weight concern (OR=1.04, p=0.02), greater anxiety disorder comorbidities (OR=1.24, p&lt;0.01), and evening chronotype (OR=1.65, p=0.03) were associated with migraine. In separate regression models for each general medical comorbidity (controlled for age, sex, and site), migraines were significantly associated with fibromyalgia (OR=3.17, p&lt;0.01), psoriasis (OR=2.65, p=0.03), and asthma (OR=2.0, p&lt;0.01). Participants with migraine were receiving ADHD medication (OR=1.53, p=0.05) or compounds associated with weight loss (OR=1.53, p=0.02) at higher rates compared to those without migraine. Limitations: Study design precludes determination of causality. Migraine subtypes and features were not assessed. Conclusions: Migraine prevalence is high in BD and is associated with a more severe clinical burden that includes increased comorbidity with pain and inflammatory conditions. Further study of the BD-migraine phenotype may provide insight into common underlying neurobiological mechanisms.</p>eng
dc.descriptionIntroduction: To evaluate the prevalence and clinical correlates of lifetime migraine among patients with bipolar disorder (BD). Methods: In a cross-sectional study, we evaluated 721 adults with BD from the Mayo Clinic Bipolar Disorder Biobank and compared clinical correlates of those with and without a lifetime history of migraine. A structured clinical interview (DSM-IV) and a clinician-assessed questionnaire were utilized to establish a BD diagnosis, lifetime history of migraine, and clinical correlates. Results: Two hundred and seven (29%) BD patients had a lifetime history of migraine. BD patients with migraine were younger and more likely to be female as compared to those without migraine (p values &lt;0.01). In a multivariate logistic regression model, younger age (OR=0.98, p&lt;0.01), female sex (OR=2.02, p&lt;0.01), higher shape/weight concern (OR=1.04, p=0.02), greater anxiety disorder comorbidities (OR=1.24, p&lt;0.01), and evening chronotype (OR=1.65, p=0.03) were associated with migraine. In separate regression models for each general medical comorbidity (controlled for age, sex, and site), migraines were significantly associated with fibromyalgia (OR=3.17, p&lt;0.01), psoriasis (OR=2.65, p=0.03), and asthma (OR=2.0, p&lt;0.01). Participants with migraine were receiving ADHD medication (OR=1.53, p=0.05) or compounds associated with weight loss (OR=1.53, p=0.02) at higher rates compared to those without migraine. Limitations: Study design precludes determination of causality. Migraine subtypes and features were not assessed. Conclusions: Migraine prevalence is high in BD and is associated with a more severe clinical burden that includes increased comorbidity with pain and inflammatory conditions. Further study of the BD-migraine phenotype may provide insight into common underlying neurobiological mechanisms.spa
dc.identifierhttps://investigadores.uandes.cl/en/publications/d882c38c-4efb-40c6-81dc-0e52460d2d6b
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/51809
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.295 (2021) date: 2021-12-01 p.156-162
dc.subjectBipolar disorder
dc.subjectComorbidity
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMigraine disorders
dc.subjectPhenotype
dc.subjectPrevalence
dc.subjectSDG 3 - Good Health and Well-being
dc.titleRevisiting the bipolar disorder with migraine phenotype: Clinical features and comorbidityeng
dc.typeArticleeng
dc.typeArtículospa
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