Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?

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dc.coverageDOI: 10.1016/j.phrs.2023.106833
dc.creatorLuarte, Alejandro
dc.creatorNardocci, Gino
dc.creatorChakraborty, Ankush
dc.creatorBatiz, Luis Federico
dc.creatorPino-Lagos, Karina
dc.creatorWyneken, Úrsula
dc.date2023
dc.date.accessioned2025-11-18T19:42:39Z
dc.date.available2025-11-18T19:42:39Z
dc.description<p>Life stressors can wreak havoc on our health, contributing to mood disorders like major depressive disorder (MDD), a widespread and debilitating condition. Unfortunately, current treatments and diagnostic strategies fall short of addressing these disorders, highlighting the need for new approaches. In this regard, the relationship between MDD, brain inflammation (neuroinflammation), and systemic inflammation in the body may offer novel insights. Recent research has uncovered the crucial role of astrocytes in coordinating the inflammatory response through the release of extracellular vesicles (ADEVs) during different neuroinflammatory conditions. While the contribution of ADEVs to stress and MDD remains largely unexplored, their potential to modulate immune cells and contribute to MDD pathogenesis is significant. In this article, we delve into the immunomodulatory role of ADEVs, their potential impact on peripheral immune cells, and how their microRNA (miRNA) landscape may hold the key to controlling immune cell activity. Together, these mechanisms may constitute an opportunity to develop novel therapeutic pharmacological approaches to tackle mood disorders.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/a128523b-697c-4625-b138-a5ea9418f2a1
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/52460
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.194 (2023)
dc.subjectAstrocyte
dc.subjectExtracellular vesicles
dc.subjectImmune response
dc.subjectMajor depressive disorder
dc.subjectNeuroinflammation
dc.subjectmiRNA
dc.titleAstrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?eng
dc.typeArticleeng
dc.typeArtículospa
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