The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

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dc.coverageDOI: 10.3389/fimmu.2021.624746
dc.creatorLuque-Campos, Noymar
dc.creatorBustamante-Barrientos, Felipe A.
dc.creatorPradenas, Carolina
dc.creatorGarcía, Cynthia
dc.creatorAraya, María Jesús
dc.creatorBohaud, Candice
dc.creatorContreras-López, Rafael
dc.creatorElizondo-Vega, Roberto
dc.creatorDjouad, Farida
dc.creatorLuz Crawford, Patricia Alejandra
dc.creatorVega-Letter, Ana María
dc.date2021
dc.date.accessioned2025-11-18T19:54:02Z
dc.date.available2025-11-18T19:54:02Z
dc.description<p>Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/eb598e10-0825-420f-930d-0a6fae770252
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/58549
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.12 (2021) date: 2021-06-04 p.624746
dc.subjectAnimals
dc.subjectCell Communication
dc.subjectCell Plasticity
dc.subjectCellular Microenvironment
dc.subjectCellular Reprogramming
dc.subjectEnergy Metabolism
dc.subjectHumans
dc.subjectInflammation Mediators/metabolism
dc.subjectMacrophages/immunology
dc.subjectMesenchymal Stem Cells/immunology
dc.subjectPhenotype
dc.subjectSignal Transduction
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogrammingeng
dc.typeArticleeng
dc.typeArtículospa
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