Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma

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dc.coverageDOI: 10.17126/joralres.2017.016
dc.creatorFernández, Alejandra
dc.creatorFernández, Javier
dc.creatorMarshall, Maureen
dc.creatorMartínez, René
dc.creatorNiklander, Sven
dc.creatorHaidar, Ziyad S.
dc.date2017
dc.date.accessioned2025-11-18T19:46:58Z
dc.date.available2025-11-18T19:46:58Z
dc.description<p>To evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods: Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31. Results: Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p&lt;0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p&lt;0.01), and between OED and OSCC groups (p&lt;0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17±4.98 in NOM, 23.40±5.77 in OED and 33.92±8.39 in OSCC. Conclusion: EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosis.</p>eng
dc.descriptionTo evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods: Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31. Results: Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p&lt;0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p&lt;0.01), and between OED and OSCC groups (p&lt;0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17±4.98 in NOM, 23.40±5.77 in OED and 33.92±8.39 in OSCC. Conclusion: EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosisspa
dc.identifierhttps://investigadores.uandes.cl/en/publications/72c9f952-9b51-4610-a58c-e06605b26e36
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/54801
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.6 (2017) nr.2 p.39-45
dc.subjectEpidermal growth factor receptor
dc.subjectMouth neoplasms
dc.subjectOral cavity
dc.subjectPathologic angiogenesis
dc.titleDifference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinomaeng
dc.typeArticleeng
dc.typeArtículospa
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