Aging and putative frailty biomarkers are altered by spaceflight

Simple item page
dc.coverageDOI: 10.1038/s41598-024-57948-5
dc.creatorCamera, Andrea
dc.creatorTabetah, Marshall
dc.creatorCastañeda, Veronica
dc.creatorKim, Jang Keun
dc.creatorGalsinh, Aman Singh
dc.creatorHaro-Vinueza, Alissen
dc.creatorSalinas, Ivonne
dc.creatorSeylani, Allen
dc.creatorArif, Shehbeel
dc.creatorDas, Saswati
dc.creatorMori, Marcelo A.
dc.creatorCarano, Anthony
dc.creatorde Oliveira, Lorraine Christine
dc.creatorMuratani, Masafumi
dc.creatorBarker, Richard
dc.creatorZaksas, Victoria
dc.creatorGoel, Chirag
dc.creatorDimokidis, Eleni
dc.creatorTaylor, Deanne M.
dc.creatorJeong, Jisu
dc.creatorOverbey, Eliah
dc.creatorMeydan, Cem
dc.creatorPorterfield, D. Marshall
dc.creatorDíaz, Juan Esteban
dc.creatorCaicedo, Andrés
dc.creatorSchisler, Jonathan C.
dc.creatorLaiakis, Evagelia C.
dc.creatorMason, Christopher E.
dc.creatorKim, Man S.
dc.creatorKarouia, Fathi
dc.creatorSzewczyk, Nathaniel J.
dc.creatorBeheshti, Afshin
dc.date2024
dc.date.accessioned2026-01-05T21:21:24Z
dc.date.available2026-01-05T21:21:24Z
dc.description<p>Human space exploration poses inherent risks to astronauts’ health, leading to molecular changes that can significantly impact their well-being. These alterations encompass genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and various epigenomic changes. Remarkably, these changes bear similarities to those observed during the aging process on Earth. However, our understanding of the connection between these molecular shifts and disease development in space remains limited. Frailty syndrome, a clinical syndrome associated with biological aging, has not been comprehensively investigated during spaceflight. To bridge this knowledge gap, we leveraged murine data obtained from NASA’s GeneLab, along with astronaut data gathered from the JAXA and Inspiration4 missions. Our objective was to assess the presence of biological markers and pathways related to frailty, aging, and sarcopenia within the spaceflight context. Through our analysis, we identified notable changes in gene expression patterns that may be indicative of the development of a frailty-like condition during space missions. These findings suggest that the parallels between spaceflight and the aging process may extend to encompass frailty as well. Consequently, further investigations exploring the utility of a frailty index in monitoring astronaut health appear to be warranted.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/8d57befb-1ca8-459e-8653-c33a10dbe454
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/69413
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.14 (2024) nr.1
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAging and putative frailty biomarkers are altered by spaceflighteng
dc.typeArticleeng
dc.typeArtículospa
Files
Collections
Pure-CRIS