Moral Emotions and Their Brain Structural Correlates Across Neurodegenerative Disorders

Simple item page
dc.coverageDOI: 10.3233/JAD-221131
dc.creatorBaez, Sandra
dc.creatorTrujillo-Llano, Catalina
dc.creatorDe Souza, Leonardo Cruz
dc.creatorLillo, Patricia
dc.creatorForno, Gonzalo
dc.creatorSantamaría-García, Hernando
dc.creatorOkuma, Cecilia
dc.creatorAlegria, Patricio
dc.creatorHuepe, David
dc.creatorIbáñez, Agustín
dc.creatorDecety, Jean
dc.creatorSlachevsky, Andrea
dc.date2023
dc.date.accessioned2026-01-05T21:22:36Z
dc.date.available2026-01-05T21:22:36Z
dc.description<p>Background: Although social cognition is compromised in patients with neurodegenerative disorders such as behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD), research on moral emotions and their neural correlates in these populations is scarce. No previous study has explored the utility of moral emotions, compared to and in combination with classical general cognitive state tools, to discriminate bvFTD from AD patients. Objective: To examine self-conscious (guilt and embarrassment) and other-oriented (pity and indignation) moral emotions, their subjective experience, and their structural brain underpinnings in bvFTD (n = 31) and AD (n = 30) patients, compared to healthy controls (n = 37). We also explored the potential utility of moral emotions measures to discriminate bvFTD from AD. Methods: We used a modified version of the Moral Sentiment Task measuring the participants' accuracy scores and their emotional subjective experiences. Results: bvFTD patients exhibited greater impairments in self-conscious and other-oriented moral emotions as compared with AD patients and healthy controls. Moral emotions combined with general cognitive state tools emerged as useful measures to discriminate bvFTD from AD patients. In bvFTD patients, lower moral emotions scores were associated with lower gray matter volumes in caudate nucleus and inferior and middle temporal gyri. In AD, these scores were associated with lower gray matter volumes in superior and middle frontal gyri, middle temporal gyrus, inferior parietal lobule and supramarginal gyrus. Conclusion: These findings contribute to a better understanding of moral emotion deficits across neurodegenerative disorders, highlighting the potential benefits of integrating this domain into the clinical assessment.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/7b3136db-7239-483a-940b-33f2f36f06d3
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/69956
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.92 (2023) nr.1 p.153-169
dc.subjectAlzheimer's disease
dc.subjectbehavioral variant frontotemporal dementia
dc.subjectmoral emotions
dc.subjectneural correlates
dc.subjectsocial cognition
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMoral Emotions and Their Brain Structural Correlates Across Neurodegenerative Disorderseng
dc.typeArticleeng
dc.typeArtículospa
Files
Collections
Pure-CRIS