MR elastography outperforms shear wave elastography for the diagnosis of clinically significant portal hypertension

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dc.coverageDOI: 10.1007/s00330-022-08935-9
dc.creatorKennedy, Paul
dc.creatorStocker, Daniel
dc.creatorCarbonell, Guillermo
dc.creatorSaid, Daniela
dc.creatorBane, Octavia
dc.creatorHectors, Stefanie
dc.creatorAbboud, Ghadi
dc.creatorCuevas, Jordan
dc.creatorBolster, Bradley D.
dc.creatorFriedman, Scott L.
dc.creatorLewis, Sara
dc.creatorSchiano, Thomas
dc.creatorBhattacharya, Dipankar
dc.creatorFischman, Aaron
dc.creatorThung, Swan
dc.creatorTaouli, Bachir
dc.date2022
dc.date.accessioned2025-11-18T19:45:46Z
dc.date.available2025-11-18T19:45:46Z
dc.description<p>Objectives: Portal hypertension (PH) is associated with complications such as ascites and esophageal varices and is typically diagnosed through invasive hepatic venous pressure gradient (HVPG) measurement, which is not widely available. In this study, we aim to assess the diagnostic performance of 2D/3D MR elastography (MRE) and shear wave elastography (SWE) measures of liver and spleen stiffness (LS and SS) and spleen volume, to noninvasively diagnose clinically significant portal hypertension (CSPH) using HVPG measurement as the reference. Methods: In this prospective study, patients with liver disease underwent 2D/3D MRE and SWE of the liver and spleen, as well as HVPG measurement. The correlation between MRE/SWE measures of LS/SS and spleen volume with HVPG was assessed. ROC analysis was used to determine the utility of MRE, SWE, and spleen volume for diagnosing CSPH. Results: Thirty-six patients (M/F 22/14, mean age 55 ± 14 years) were included. Of the evaluated parameters, 3D MRE SS had the strongest correlation with HVPG (r = 0.686, p &lt; 0.001), followed by 2D MRE SS (r = 0.476, p = 0.004). 3D MRE SS displayed the best performance for diagnosis of CSPH (AUC = 0.911) followed by 2D MRE SS (AUC = 0.845) and 3D MRE LS (AUC = 0.804). SWE SS showed poor performance for diagnosis of CSPH (AUC = 0.583) while spleen volume was a fair predictor (AUC = 0.738). 3D MRE SS was significantly superior to SWE LS/SS (p ≤ 0.021) for the diagnosis of CSPH. Conclusion: SS measured with 3D MRE outperforms SWE for the diagnosis of CSPH. SS appears to be a useful biomarker for assessing PH severity. These results need further validation. Key Points: • Spleen stiffness measured with 2D and 3D MR elastography correlates significantly with hepatic venous pressure gradient measurement. • Spleen stiffness measured with 3D MR elastography demonstrates excellent performance for the diagnosis of clinically significant portal hypertension (AUC 0.911). • Spleen stiffness measured with 3D MR elastography outperforms liver and spleen stiffness measured with shear wave elastography for diagnosis of clinically significant portal hypertension.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/6de453a3-4f51-4ca2-99ec-823924f8a5ef
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/54148
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.32 (2022) nr.12 p.8339-8349
dc.subjectElasticity imaging techniques
dc.subjectHypertension, portal
dc.subjectLiver
dc.subjectSpleen
dc.titleMR elastography outperforms shear wave elastography for the diagnosis of clinically significant portal hypertensioneng
dc.typeArticleeng
dc.typeArtículospa
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