Retrospective analysis of chilean and Mexican GI stromal tumor registries: A tale of two Latin American realities

Simple item page
dc.coverageDOI: 10.1200/JGO.19.00410
dc.creatorCalderillo, Germán
dc.creatorMuñoz-Medel, Matías
dc.creatorCarbajal, Edelmira
dc.creatorCórdova-Delgado, Miguel
dc.creatorDurán, Doris
dc.creatorRetamal, Ignacio N.
dc.creatorFernández, Piga
dc.creatorEspinoza, Absalón
dc.creatorSalas, Rodrigo
dc.creatorDe La Paz Mastretta, María
dc.creatorGalindo, Héctor
dc.creatorNervi, Bruno
dc.creatorMadrid, Jorge
dc.creatorSánchez, Cesar
dc.creatorIbáñez, Carolina
dc.creatorPeña, José
dc.creatorMondaca, Sebastián
dc.creatorAcevedo, Francisco
dc.creatorKoch, Erica
dc.creatorPinto, Mauricio P.
dc.creatorGarrido, Marcelo
dc.date2020
dc.date.accessioned2025-11-18T19:41:44Z
dc.date.available2025-11-18T19:41:44Z
dc.description<p>Purpose: Like other malignancies, GI stromal tumors (GIST) are highly heterogeneous. This not only applies to histologic features and malignant potential, but also to geographic incidence rates. Several studies have reported GIST incidence and prevalence in Europe and North America. In contrast, GIST incidence rates in South America are largely unknown, and only a few studies have reported GIST prevalence in Latin America. Patients and Methods: Our study was part of a collaborative effort between Chile and Mexico, called Salud con Datos. We sought to determine GIST prevalence and patients' clinical characteristics, including survival rates, through retrospective analysis. Results: Overall, 624 patients were included in our study. Our results found significant differences between Mexican and Chilean registries, such as stage at diagnosis, primary tumor location, CD117-positive immunohistochemistry status, mitotic index, and tumor size. Overall survival (OS) times for Chilean and Mexican patients with GIST were 134 and 156 months, respectively. No statistically significant differences in OS were detected by sex, age, stage at diagnosis, or recurrence status in both cohorts. As expected, patients categorized as being at high risk of recurrence displayed a trend toward poorer progression-free survival in both registries. Conclusion: To the best of our knowledge, this is the largest report from Latin America assessing the prevalence, clinical characteristics, postsurgery risk of recurrence, and outcomes of patients with GIST. Our data confirm surgery as the standard treatment of localized disease and confirm a poorer prognosis in patients with regional or distant disease. Finally, observed differences between registries could be a result of registration bias. </p>eng
dc.descriptionPurpose: Like other malignancies, GI stromal tumors (GIST) are highly heterogeneous. This not only applies to histologic features and malignant potential, but also to geographic incidence rates. Several studies have reported GIST incidence and prevalence in Europe and North America. In contrast, GIST incidence rates in South America are largely unknown, and only a few studies have reported GIST prevalence in Latin America. Patients and Methods: Our study was part of a collaborative effort between Chile and Mexico, called Salud con Datos. We sought to determine GIST prevalence and patients' clinical characteristics, including survival rates, through retrospective analysis. Results: Overall, 624 patients were included in our study. Our results found significant differences between Mexican and Chilean registries, such as stage at diagnosis, primary tumor location, CD117-positive immunohistochemistry status, mitotic index, and tumor size. Overall survival (OS) times for Chilean and Mexican patients with GIST were 134 and 156 months, respectively. No statistically significant differences in OS were detected by sex, age, stage at diagnosis, or recurrence status in both cohorts. As expected, patients categorized as being at high risk of recurrence displayed a trend toward poorer progression-free survival in both registries. Conclusion: To the best of our knowledge, this is the largest report from Latin America assessing the prevalence, clinical characteristics, postsurgery risk of recurrence, and outcomes of patients with GIST. Our data confirm surgery as the standard treatment of localized disease and confirm a poorer prognosis in patients with regional or distant disease. Finally, observed differences between registries could be a result of registration bias.spa
dc.identifierhttps://investigadores.uandes.cl/en/publications/0ec36203-9490-4d45-8778-fb7e83ea0e2f
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/51979
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.source(2020) date: 2020-04-23 nr.6 p.647-657
dc.subjectGastrointestinal stromal tumors
dc.subjectNeoplasm recurrence
dc.subjectRegistries
dc.subjectSDG 3 - Good Health and Well-being
dc.titleRetrospective analysis of chilean and Mexican GI stromal tumor registries: A tale of two Latin American realitieseng
dc.typeArticleeng
dc.typeArtículospa
Files
Collections
PURE