Severe acute respiratory syndrome Coronavirus 2 antibody prevalence in blood in a large school community subject to a Coronavirus disease 2019 outbreak: A cross-sectional study

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dc.coverageDOI: 10.1093/cid/ciaa955
dc.creatorTorres, Juan Pablo
dc.creatorPiñera, Cecilia
dc.creatorDe La Maza, Verónica
dc.creatorLagomarcino, Anne J.
dc.creatorSimian, Daniela
dc.creatorTorres, Bárbara
dc.creatorUrquidi, Cinthya
dc.creatorValenzuela, María Teresa
dc.creatorO'Ryan, Miguel
dc.date2021
dc.date.accessioned2025-11-18T19:54:10Z
dc.date.available2025-11-18T19:54:10Z
dc.description<p>Background. A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak affecting 52 people from a large school community in Santiago, Chile, was identified (12 March) 9 days after the first case in the country. We assessed the magnitude of the outbreak and the role students and staff played using self-administered antibody detection tests and a self-administered survey. Methods. The school was closed on 13 March, and the entire community was placed under quarantine. We implemented a home-delivery, self-administered, immunoglobin (Ig) G/IgM antibody test and survey to a classroom-stratified sample of students and all staff from 4-19 May. We aimed to determine the overall seroprevalence rates by age group, reported symptoms, and contact exposure, and to explore the dynamics of transmission. Results. The antibody positivity rates were 9.9% (95% confidence interval [CI], 8.2-11.8) for 1009 students and 16.6% (95% CI, 12.1- 21.9) for 235 staff. Among students, positivity was associated with a younger age (P = .01), a lower grade level (P = .05), prior real-time polymerase chain reaction (RT-PCR) positivity (P = .03), and a history of contact with a confirmed case (P &lt; .001). Among staff, positivity was higher in teachers (P = .01) and in those previously RT-PCR positive (P &lt; .001). Excluding RT-PCR-positive individuals, antibody positivity was associated with fever in adults and children (P = .02 and P = .002, respectively), abdominal pain in children (P = .001), and chest pain in adults (P = .02). Within antibody-positive individuals, 40% of students and 18% of staff reported no symptoms (P = .01). Conclusions. Teachers were more affected during the outbreak and younger children were at a higher risk for infection, likely because index case(s) were teachers and/or parents from the preschool. Self-administered antibody testing, supervised remotely, proved to be a suitable and rapid tool. Our study provides useful information for school reopenings.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/ad72a487-d99c-44ef-b0dc-f93adbceae01
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/58612
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.73 (2021) date: 2021-07-15 nr.2 p.E458-E465
dc.subjectAdult
dc.subjectCOVID-19
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectChile
dc.subjectCross-Sectional Studies
dc.subjectDisease Outbreaks
dc.subjectHumans
dc.subjectPrevalence
dc.subjectSARS-CoV-2
dc.subjectSchools
dc.subjectSeroepidemiologic Studies
dc.titleSevere acute respiratory syndrome Coronavirus 2 antibody prevalence in blood in a large school community subject to a Coronavirus disease 2019 outbreak: A cross-sectional studyeng
dc.typeArticleeng
dc.typeArtículospa
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