Turning adversity into opportunity: Small extracellular vesicles as nanocarriers for tumor-associated macrophages re-education

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dc.coverageDOI: 10.1002/btm2.10349
dc.creatorDonoso-Meneses, Dario
dc.creatorFigueroa-Valdés, Aliosha I.
dc.creatorGeorges, Nicolás
dc.creatorTobar, Hugo E.
dc.creatorAlcayaga-Miranda, Francisca
dc.date2023
dc.date.accessioned2025-11-18T19:42:02Z
dc.date.available2025-11-18T19:42:02Z
dc.description<p>Currently, small extracellular vesicles (sEV) as a nanoscale drug delivery system, are undergoing biotechnological scaling and clinical validation. Nonetheless, preclinical pharmacokinetic studies revealed that sEV are predominantly uptaken by macrophages. Although this “sEV-macrophage” propensity represents a disadvantage in terms of sEV targeting and their bioavailability as nanocarriers, it also represents a strategic advantage for those therapies that involve macrophages. Such is the case of tumor-associated macrophages (TAMs), which can reprogram/repolarize their predominantly immunosuppressive and tumor-supportive phenotype toward an immunostimulatory and anti-tumor phenotype using sEV as nanocarriers of TAMs reprogramming molecules. In this design, sEV represents an advantageous delivery system, providing precision to the therapy by simultaneously matching their tropism to the therapeutic cell target. Here, we review the current knowledge of the role of TAMs in the tumoral microenvironment and the effect generated by the reprogramming of these phagocytic cells fate using sEV. Finally, we discuss how these vesicles can be engineered by different bioengineering techniques to improve their therapeutic cargo loading and preferential uptake by TAMs.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/1f036b8d-6ce1-460f-bd8f-2d32eb4211cd
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/52129
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.8 (2023) nr.1
dc.subjectTAMs re-education
dc.subjectcancer
dc.subjectimmunotherapy
dc.subjectmacrophages
dc.subjectnanocarrier engineering
dc.subjectsmall extracellular vesicles
dc.subjectSDG 3 - Good Health and Well-being
dc.titleTurning adversity into opportunity: Small extracellular vesicles as nanocarriers for tumor-associated macrophages re-educationeng
dc.typeReview articleeng
dc.typeArtículo de revisiónspa
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