Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice

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dc.coverageDOI: 10.3389/fimmu.2020.00696
dc.creatorHidalgo, Yessia
dc.creatorNúñez, Sarah
dc.creatorFuenzalida, Maria Jose
dc.creatorFlores-Santibáñez, Felipe
dc.creatorSáez, Pablo J.
dc.creatorDorner, Jessica
dc.creatorLennon-Dumenil, Ana Maria
dc.creatorMartínez, Victor
dc.creatorZorn, Emmanuel
dc.creatorRosemblatt, Mario
dc.creatorSauma, Daniela
dc.creatorBono, Maria Rosa
dc.date2020
dc.date.accessioned05-01-2026 18:16
dc.date.available05-01-2026 18:16
dc.description<p>Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production, and immune complex deposition in various organs. Previous evidence showed abnormal accumulation of B cells in the thymus of lupus-prone mice, but the role of this population in the progression of the disease remains mostly undefined. Here we analyzed the spatial distribution, function, and properties of this thymic B cell population in the BWF1 murine model of SLE. We found that in diseased animals, thymic B cells proliferate, and cluster in structures that resemble ectopic germinal centers. Moreover, we detected antibody-secreting cells in the thymus of diseased-BWF1 mice that produce anti-dsDNA IgG autoantibodies. We also found that thymic B cells from diseased-BWF1 mice induced the differentiation of thymocytes to follicular helper T cells (T<sub>FH</sub>). These data suggest that the accumulation of B cells in the thymus of BWF1 mice results in the formation of germinal center-like structures and the expansion of a T<sub>FH</sub> population, which may, in turn, activate and differentiate B cells into autoreactive plasma cells. Therefore, the thymus emerges as an important niche that supports the maintenance of the pathogenic humoral response in the development of murine SLE.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/ba4e1fbd-dde3-494a-9653-ac0ef93cbfbb
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.11 (2020) date: 2020-04-28
dc.subjectfollicular helper T cells
dc.subjectgerminal center
dc.subjectplasma cells
dc.subjectsystemic lupus erythematosus
dc.subjectthymic B cells
dc.titleThymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Miceeng
dc.typeArticleeng
dc.typeArtículospa
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