Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice

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dc.coverageDOI: 10.1016/j.xcrm.2024.101593
dc.creatorAcuña-Catalán, Diego
dc.creatorShah, Samah
dc.creatorWehrfritz, Cameron
dc.creatorNomura, Mitsunori
dc.creatorAcevedo, Alejandro
dc.creatorOlmos, Cristina
dc.creatorQuiroz, Gabriel
dc.creatorHuerta, Hernán
dc.creatorBons, Joanna
dc.creatorAmpuero, Estibaliz
dc.creatorWyneken, Ursula
dc.creatorSanhueza, Magdalena
dc.creatorArancibia, Felipe
dc.creatorContreras, Darwin
dc.creatorCárdenas, Julio César
dc.creatorMorales, Bernardo
dc.creatorSchilling, Birgit
dc.creatorNewman, John C.
dc.creatorGonzález-Billault, Christian
dc.date2024
dc.date.accessioned2025-11-18T19:55:22Z
dc.date.available2025-11-18T19:55:22Z
dc.description<p>Aging compromises brain function leading to cognitive decline. A cyclic ketogenic diet (KD) improves memory in aged mice after long-term administration; however, short-term effects later in life and the molecular mechanisms that govern such changes remain unclear. Here, we explore the impact of a short-term KD treatment starting at elderly stage on brain function of aged mice. Behavioral testing and long-term potentiation (LTP) recordings reveal that KD improves working memory and hippocampal LTP. Furthermore, the synaptosome proteome of aged mice fed a KD long-term evidence changes predominantly at the presynaptic compartment associated to the protein kinase A (PKA) signaling pathway. These findings were corroborated in vivo by western blot analysis, with high BDNF abundance and PKA substrate phosphorylation. Overall, we show that a KD modifies brain function even when it is administered later in life and recapitulates molecular features of long-term administration, including the PKA signaling pathway, thus promoting synaptic plasticity at advanced age.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/a1c64871-510d-45cc-8bd4-e0db43d44808
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/59221
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.5 (2024) date: 2024-06-18 nr.6 p.101593
dc.subjectBDNF
dc.subjectLTP
dc.subjectPKA
dc.subjectaging
dc.subjectbrain-derived neurotrophic factor
dc.subjectketogenic diet
dc.subjectlong-term potentiation
dc.subjectprotein kinase A
dc.subjectproteomics
dc.subjectβ-hydroxybutyrate
dc.titleKetogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging miceeng
dc.typeArticleeng
dc.typeArtículospa
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