Soluble neuropilin-1 in gingival crevicular fluid is associated with rheumatoid arthritis: An exploratory case-control study

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dc.coverageDOI: 10.1016/j.jobcr.2021.02.010
dc.creatorPrieto, Diego
dc.creatorGonzález, Camila
dc.creatorWeber, Laura
dc.creatorRealini, Ornella
dc.creatorPino-Lagos, Karina
dc.creatorBendek, Maria José
dc.creatorRetamal, Ignacio
dc.creatorBeltrán, Víctor
dc.creatorRiedemann, Juan Pablo
dc.creatorEspinoza, Francisco
dc.creatorChaparro, Alejandra
dc.date2021
dc.date.accessioned2025-11-18T19:40:55Z
dc.date.available2025-11-18T19:40:55Z
dc.description<p>Background: To explore the soluble Neuropilin-1 (sNRP-1) concentrations in gingival crevicular fluid (GCF) and the periodontal clinical status of patients with Rheumatoid Arthritis (RA). Materials and methods: We conducted an exploratory study with 40 study participants, 20 with RA, and 20 healthy controls. Clinical and periodontal data were recorded, and GCF samples were obtained. sNRP-1 levels in GCF were determined by ELISA assay. Descriptive statistics, Mann–Whitney U test, Unpaired t-test, logistic regression model, and Area Under Receiver Operating Characteristic Curve (AUC-ROC) were made to explore the diagnostic performance accuracy. Results: RA patients had significantly higher levels of sNRP-1 in GCF (p ​= ​0.0447). The median levels of GCF-sNRP-1 were 208.85 ​pg/μl (IQR 131.03) in the RA group compared to 81.46 ​pg/μl (IQR 163.73) in the control group. We observed an association between the GCF-sNRP-1 concentrations and the RA diagnosis (OR:1.009; CI 1.00–1.001; p ​= ​0.047). The diagnosis of chronic periodontitis was also associated with RA (OR: 6.9; CI 1.52–31.37; p ​= ​0.012). Moreover, the AUC-ROC of GCF-sNRP-1 concentrations combined with periodontal clinical parameters such as periodontal probing depth and periodontal inflamed surface area was 0.80. Conclusion: This exploratory case-control study shows that RA patients had significantly higher levels of sNRP-1 in GCF. New longitudinal studies are necessary to evaluate the role of NRP-1 in periodontal tissues and consider it an oral biomarker with clinical value in RA.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/a23f139e-f7ca-43cb-9c4f-98e20f529f11
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/51541
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.11 (2021) date: 2021-04-01 nr.2 p.303-307
dc.subjectGingival crevicular fluid
dc.subjectNeuropilin-1
dc.subjectPeriodontitis
dc.subjectRheumatoid arthritis
dc.titleSoluble neuropilin-1 in gingival crevicular fluid is associated with rheumatoid arthritis: An exploratory case-control studyeng
dc.typeArticleeng
dc.typeArtículospa
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