Routine screening for SARS CoV-2 in unselected pregnant women at delivery

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dc.coverageDOI: 10.1371/journal.pone.0239887
dc.creatorDíaz-Corvillón, Pilar
dc.creatorMönckeberg, Max
dc.creatorBarros, Antonia
dc.creatorIllanes, Sebastián E.
dc.creatorSoldati, Arturo
dc.creatorNien, Jyh Kae
dc.creatorSchepeler, Manuel
dc.creatorCaradeux, Javier
dc.date2020
dc.date.accessioned2025-11-18T19:46:47Z
dc.date.available2025-11-18T19:46:47Z
dc.descriptionThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background South America has become the epicenter of coronavirus pandemic. It seems that asymptomatic population may contribute importantly to the spread of the disease. Transmission from asymptomatic pregnant patients’ needs to be characterized in larger population cohorts and symptom assessment needs to be standardized. Objective To assess the prevalence of SARS CoV-2 infection in an unselected obstetrical population and to describe their presentation and clinical evolution. Methods A cross-sectional study was designed. Medical records of pregnant women admitted at the Obstetrics & Gynecology department of Clínica Dávila for labor & delivery, between April 27th and June 7th, 2020 were reviewed. All patients were screened with RT-PCR for SARS CoV-2 at admission. After delivery, positive cases were inquired by the researchers for clinical symptoms presented before admission and clinical evolution. All neonates born from mothers with confirmed SARS CoV-2 were isolated and tested for SARS CoV-2 infection. Results A total of 586 patients were tested for SARS CoV-2 during the study period. Outcomes were obtained from 583 patients which were included in the study. Thirty-seven pregnant women had a positive test for SARS CoV-2 at admission. Cumulative prevalence of confirmed SARS CoV-2 infection was 6.35% (37/583) [CI 95%: 4.63–8.65]. From confirmed cases, 43.2% (16/37) were asymptomatic. From symptomatic patients 85.7% (18/21) had mild symptoms and evolved without complications and 14.3% (3/21) presented severe symptoms requiring admission to intensive care unit. Only 5.4% (2/37) of the neonates born to mothers with a positive test at admission had a positive RT-PCR for SARS CoV-2. Conclusion In our study nearly half of pregnant patients with SARS CoV-2 were asymptomatic at the time of delivery. Universal screening, in endemic areas, is necessary for adequate patient isolation, prompt neonatal testing and targeted follow-up.eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/b822879d-afaa-4f80-a3e9-c517ccf601b6
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/54701
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.15 (2020) date: 2020-09-01 nr.9 September p.e0239887
dc.subjectAdult
dc.subjectAsymptomatic Infections
dc.subjectBetacoronavirus
dc.subjectCOVID-19
dc.subjectCOVID-19 Testing
dc.subjectChile/epidemiology
dc.subjectClinical Laboratory Techniques
dc.subjectCoronavirus Infections/diagnosis
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectMass Screening
dc.subjectPandemics
dc.subjectPneumonia, Viral/diagnosis
dc.subjectPregnancy
dc.subjectPregnancy Complications, Infectious/diagnosis
dc.subjectPregnant Women
dc.subjectPrevalence
dc.subjectSARS-CoV-2
dc.subjectYoung Adult
dc.titleRoutine screening for SARS CoV-2 in unselected pregnant women at deliveryeng
dc.typeArticleeng
dc.typeArtículospa
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