Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer

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dc.coverageDOI: 10.1038/s41467-022-34407-1
dc.creatorBusso-Lopes, Ariane F.
dc.creatorNeves, Leandro X.
dc.creatorCâmara, Guilherme A.
dc.creatorGranato, Daniela C.
dc.creatorPretti, Marco Antônio M.
dc.creatorHeberle, Henry
dc.creatorPatroni, Fábio M.S.
dc.creatorSá, Jamile
dc.creatorYokoo, Sami
dc.creatorRivera, César
dc.creatorDomingues, Romênia R.
dc.creatorNormando, Ana Gabriela C.
dc.creatorDe Rossi, Tatiane
dc.creatorMello, Barbara P.
dc.creatorGaldino, Nayane A.L.
dc.creatorPauletti, Bianca A.
dc.creatorLacerda, Pammela A.
dc.creatorRodrigues, André Afonso N.
dc.creatorCasarim, André Luis M.
dc.creatorde Lima-Souza, Reydson A.
dc.creatorDamas, Ingrid I.
dc.creatorMariano, Fernanda V.
dc.creatorGollob, Kenneth J.
dc.creatorMedina, Tiago S.
dc.creatorCervigne, Nilva K.
dc.creatorPrado-Ribeiro, Ana Carolina
dc.creatorBrandão, Thaís Bianca
dc.creatorVilla, Luisa L.
dc.creatorUno, Miyuki
dc.creatorBoroni, Mariana
dc.creatorKowalski, Luiz Paulo
dc.creatorGonzález-Arriagada, Wilfredo Alejandro
dc.creatorPaes Leme, Adriana F.
dc.date2022
dc.date.accessioned2025-11-18T19:48:53Z
dc.date.available2025-11-18T19:48:53Z
dc.description<p>The poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN-negative or -positive tissues, saliva, and blood cells, reveals insights into the biology and potential metastasis biomarkers that may assist in clinical decision-making. Protein profiles are strictly associated with immune modulation across datasets, and this provides the basis for investigating immune markers associated with metastasis. The proteome of LN metastatic cells recapitulates the proteome of the primary tumor sites. Conversely, the LN microenvironment proteome highlights the candidate prognostic markers. By integrating prioritized peptide, protein, and transcript levels with machine learning models, we identify nodal metastasis signatures in blood and saliva. We present a proteomic characterization wiring multiple sites in HNC, thus providing a promising basis for understanding tumoral biology and identifying metastasis-associated signatures.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/4fd22b64-e165-4675-b90e-fecd74ef8889
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55799
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.13 (2022) nr.1 p.1-24
dc.subjectSDG 3 - Good Health and Well-being
dc.titleConnecting multiple microenvironment proteomes uncovers the biology in head and neck cancereng
dc.typeArticleeng
dc.typeArtículospa
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