Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos

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dc.coverageDOI: 10.3389/fcell.2024.1460697
dc.creatorQuiroz, Alonso
dc.creatorBelledonne, Gabriela
dc.creatorSaavedra, Fujiko
dc.creatorGonzález, Javier
dc.creatorBusso, Dolores
dc.date2024
dc.date.accessioned2025-11-18T19:50:31Z
dc.date.available2025-11-18T19:50:31Z
dc.description<p>Introduction: Genetic and environmental factors influence the risk of neural tube defects (NTD), congenital malformations characterized by abnormal brain and spine formation. Mouse embryos deficient in Scavenger Receptor Class B Type 1 (SR-B1), which is involved in the bidirectional transfer of lipids between lipoproteins and cells, exhibit a high prevalence of exencephaly, preventable by maternal vitamin E supplementation. SR-B1 knock-out (KO) embryos are severely deficient in vitamin E and show elevated reactive oxygen species levels during neurulation. Methods: We fed SR-B1 heterozygous female mice a high-fat/high-sugar (HFHS) diet and evaluated the vitamin E and oxidative status in dams and embryos from heterozygous intercrosses. We also determined the incidence of NTD. Results and discussion: HFHS-fed SR-B1 HET females exhibited altered glucose metabolism and excess circulating lipids, along with a higher incidence of embryos with developmental delay and NTD. Vitamin E supplementation partially mitigated HFHS-induced maternal metabolic abnormalities and completely prevented embryonic malformations, likely through indirect mechanisms involving the reduction of oxidative stress and improved lipid handling by the parietal yolk sac.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/c82ed7c7-0750-4d08-845d-4b373bca791c
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/56655
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.12 (2024) p.1460697
dc.subjectembryo development
dc.subjectmalnutrition by excess
dc.subjectneural tube defects
dc.subjectSR-B1 deficiency
dc.subjectvitamin E
dc.subjectSDG 2 - Zero Hunger
dc.titleVitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryoseng
dc.typeArticleeng
dc.typeArtículospa
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