Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis

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dc.coverageDOI: 10.3390/ijerph19148388
dc.creatorFlores, Valentina
dc.creatorVenegas, Bernardo
dc.creatorDonoso, Wendy
dc.creatorUlloa, Camilo
dc.creatorChaparro, Alejandra
dc.creatorSousa, Vanessa
dc.creatorBeltrán, Víctor
dc.date2022
dc.date.accessioned2025-11-18T19:48:45Z
dc.date.available2025-11-18T19:48:45Z
dc.description<p>Currently, researchers are focused on the study of cytokines as predictive biomarkers of peri-implantitis (PI) in order to obtain an early diagnosis and prognosis, and for treatment of the disease. The aim of the study was to characterize the peri-implant soft and hard tissues in patients with a peri-implantitis diagnosis. A descriptive observational study was conducted. Fifteen soft tissue (ST) samples and six peri-implant bone tissue (BT) samples were obtained from 13 patients who were diagnosed with peri-implantitis. All the samples were processed and embedded in paraffin for histological and immunohistochemical analyses. A descriptive and quantitative analysis of mast cells and osteocytes, A proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF), osteonectin (ON), and ∝-smooth muscle actin (∝-SMA) was performed. We observed the presence of mast cells in peri-implant soft tissue in all samples (mean 9.21 number of mast cells) and osteocytes in peri-implant hard tissue in all samples (mean 37.17 number of osteocytes). The expression of APRIL-ST was 32.17% ± 6.39%, and that of APRIL-BT was 7.09% ± 5.94%. The BAFF-ST expression was 17.26 ± 12.90%, and the BAFF-BT was 12.16% ± 6.30%. The mean percentage of ON was 7.93% ± 3.79%, and ∝-SMA was 1.78% ± 3.79%. It was concluded that the expression of APRIL and BAFF suggests their involvement in the bone resorption observed in peri-implantitis. The lower expression of osteonectin in the peri-implant bone tissue can also be associated with a deficiency in the regulation of bone remodeling and the consequent peri-implant bone loss.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/b449e2b9-e19a-4398-b153-d7877023b87d
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55718
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.19 (2022) date: 2022-07-08 nr.14 p.1-9
dc.subjectAPRIL/BAFF
dc.subjectoral health
dc.subjectosteonectin
dc.subjectperi-implant disease
dc.subjectperi-implantitis
dc.subject∝-smooth muscle actin
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHistological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitiseng
dc.typeArticleeng
dc.typeArtículospa
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