The Intersection of the Oral Microbiome and Salivary Metabolites in Head and Neck Cancer: From Diagnosis to Treatment
| dc.coverage | DOI: 10.3390/cancers16203545 | |
| dc.creator | Gonzalez Agurto, Maria | |
| dc.creator | Olivares, Nicolas | |
| dc.creator | Canedo-Marroquin, Gisela | |
| dc.creator | Espinoza, Daniela | |
| dc.creator | Tortora, Sofia C. | |
| dc.date | 2024 | |
| dc.date.accessioned | 2025-11-18T19:55:39Z | |
| dc.date.available | 2025-11-18T19:55:39Z | |
| dc.description | <p>Head and neck cancers (HNCs) represent 4–5% of all malignancies globally. Salivary metabolites, as metabolic intermediates and signalling molecules, are gaining attention as diagnostic biomarkers for several diseases, including HNC; however, the metabolites’ role in cancer treatment outcomes and oral side effects remains underexplored. Current studies focus on the oral microbiome’s significance in promoting a pro-inflammatory environment that facilitates tumour development and invasion. Specific microorganisms and their metabolites influence chemotherapy efficacy through several mechanisms. Radiotherapy (RT), a standard HNC treatment, can modify the oral microbiota and salivary metabolite profiles, leading to a wide range of side effects. To reduce oral complications, intensity-modulated radiotherapy (IMRT) was developed; however, cancer survivors often experience a reduced quality of life. This review highlights the microbial and host interactions affecting salivary metabolites and their implications for cancer treatment and patient outcomes.</p> | eng |
| dc.identifier | https://investigadores.uandes.cl/en/publications/cb2e04e6-03b7-4a85-9fc5-49eef81e199d | |
| dc.identifier.uri | https://repositorio.uandes.cl/handle/uandes/59378 | |
| dc.language | eng | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | vol.16 (2024) nr.20 | |
| dc.subject | dysbiosis | |
| dc.subject | head and neck cancer | |
| dc.subject | metabolites | |
| dc.subject | mucin | |
| dc.subject | oral microbiota | |
| dc.subject | radiotherapy | |
| dc.subject | saliva | |
| dc.subject | SDG 3 - Good Health and Well-being | |
| dc.title | The Intersection of the Oral Microbiome and Salivary Metabolites in Head and Neck Cancer: From Diagnosis to Treatment | eng |
| dc.type | Review article | eng |
| dc.type | Artículo de revisión | spa |