Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder

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dc.coverageDOI: 10.1038/s41398-024-02798-y
dc.creatorNuñez, Nicolas A.
dc.creatorCoombes, Brandon J.
dc.creatorBeaupre, Lindsay Melhuish
dc.creatorOzerdem, Aysegul
dc.creatorResendez, Manuel Gardea
dc.creatorRomo-Nava, Francisco
dc.creatorBond, David J.
dc.creatorVeldic, Marin
dc.creatorSingh, Balwinder
dc.creatorMoore, Katherine M.
dc.creatorBetcher, Hannah K.
dc.creatorKung, Simon
dc.creatorPrieto, Miguel L.
dc.creatorFuentes, Manuel
dc.creatorErcis, Mete
dc.creatorMiola, Alessandro
dc.creatorSanchez Ruiz, Jorge A.
dc.creatorJenkins, Gregory
dc.creatorBatzler, Anthony
dc.creatorLeung, Jonathan G.
dc.creatorCuellar-Barboza, Alfredo
dc.creatorTye, Susannah J.
dc.creatorMcElroy, Susan L.
dc.creatorBiernacka, Joanna M.
dc.creatorFrye, Mark A.
dc.date2024
dc.date.accessioned2025-11-18T19:49:37Z
dc.date.available2025-11-18T19:49:37Z
dc.description<p>There is increasing interest in individualizing treatment selection for more than 25 regulatory approved treatments for major depressive disorder (MDD). Despite an inconclusive efficacy evidence base, antidepressants (ADs) are prescribed for the depressive phase of bipolar disorder (BD) with oftentimes, an inadequate treatment response and or clinical concern for mood destabilization. This study explored the relationship between antidepressant response in MDD and antidepressant-associated treatment emergent mania (TEM) in BD. We conducted a genome-wide association study (GWAS) and polygenic score analysis of TEM and tested its association in a subset of BD-type I patients treated with SSRIs or SNRIs. Our results did not identify any genome-wide significant variants although, we found that a higher polygenic score (PGS) for antidepressant response in MDD was associated with higher odds of TEM in BD. Future studies with larger transdiagnostic depressed cohorts treated with antidepressants are encouraged to identify a neurobiological mechanism associated with a spectrum of depression improvement from response to emergent mania.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/647fc110-a36d-471d-86a4-4363b28b637d
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/56188
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.14 (2024) date: 2024-02-13 nr.1 p.1-5
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePharmacogenomic overlap between antidepressant treatment response in major depression &amp; antidepressant associated treatment emergent mania in bipolar disordereng
dc.typeArticleeng
dc.typeArtículospa
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