Standardization of Animal Models and Techniques for Platelet-Rich Fibrin Production: A Narrative Review and Guideline

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dc.coverageDOI: 10.3390/bioengineering10040482
dc.creatorMourão, Carlos Fernando
dc.creatorLowenstein, Adam
dc.creatorMello-Machado, Rafael Coutinho
dc.creatorGhanaati, Shahram
dc.creatorPinto, Nelson
dc.creatorKawase, Tomoyuki
dc.creatorAlves, Gutemberg Gomes
dc.creatorMessora, Michel Reis
dc.date2023
dc.date.accessioned2025-11-18T19:42:32Z
dc.date.available2025-11-18T19:42:32Z
dc.description<p>Experimental research is critical for advancing medical knowledge and enhancing patient outcomes, including in vitro and in vivo preclinical assessments. Platelet-rich fibrin (PRF) is a blood by-product that has garnered attention in the medical and dental fields due to its potential for tissue regeneration and wound healing. Animal models, such as rabbits and rats, have been used to produce PRF and examine its properties and applications. PRF has demonstrated potential in the dental and medical fields for reducing inflammation, promoting tissue repair, and accelerating wound healing. This narrative review aims to compare existing evidence and provide guidelines for PRF animal research, emphasizing the importance of standardizing animal models, following ethical considerations, and maintaining transparency and accountability. The authors highlight the necessity to use the correct relative centrifugal force (RCF), standardize centrifugal calibration, and report detailed information about blood collection and centrifuge parameters for reproducible results. Standardizing animal models and techniques is crucial for narrowing the gap between laboratory research and clinical applications, ultimately enhancing the translation of findings from bench to bedside.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/5fe4549e-ae64-4f12-b31e-9102eb5b7142
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/52404
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.10 (2023) nr.4 p.1-18
dc.subjectanimal models
dc.subjectexperimental research
dc.subjectguideline
dc.subjectplatelet-rich fibrin
dc.titleStandardization of Animal Models and Techniques for Platelet-Rich Fibrin Production: A Narrative Review and Guidelineeng
dc.typeReview articleeng
dc.typeArtículo de revisiónspa
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