Maternal Supraphysiological Hypercholesterolemia Is Accompanied by Shifts in the Composition and Anti-Atherogenic Functions of Maternal HDL along with Maternal Cardiovascular Risk Markers at Term of Pregnancy

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dc.coverageDOI: 10.3390/antiox12101804
dc.creatorCantin, Claudette
dc.creatorMorales, Andrea
dc.creatorSerra, Ramón
dc.creatorIllanes, Sebastián E.
dc.creatorLeiva, Andrea
dc.date2023
dc.date.accessioned2025-11-18T19:55:04Z
dc.date.available2025-11-18T19:55:04Z
dc.description<p>Background: Maternal physiological hypercholesterolemia (MPH) occurs in pregnancy for a proper fetal development. When cholesterol increases over the physiological range, maternal supraphysiological hypercholesterolemia (MSPH) is described, a condition underdiagnosed by a lack of evidence showing its biological and clinical relevance. Aim: To determine if MSPH associates with maternal vascular dysfunction, along with changes in the composition and function of maternal HDL leading to increased cardiovascular risk. Methods: This study included 57 women at term of pregnancy in which a lipid profile was determined. Results: Maternal total cholesterol (TC) and LDL but not HDL were increased in MSPH women. The isolated HDL from a subgroup of MSPH women had a lower protein abundance and a reduced activity of the antioxidant enzyme PON1; however, an increased antioxidant capacity compared to MPH was observed, along with higher serum levels of α-tocopherol. Moreover, HDL from a subgroup of MSPH women had a lower capacity to induce NO synthesis in endothelial cells compared to MPH. In the circulation, we observed a reduced total antioxidant capacity and augmented levels of soluble VCAM, ApoB, ApoCII, ApoCIII, IL-10, and IL-12p70, as well as the cardiovascular risk ratio ApoB/ApoAI, compared to MPH women. Conclusion: MSPH women present dysfunctional HDL and increased atherogenic cardiovascular risk factors.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/01bab25d-c2c4-47b1-8ea2-ba61a3f65a21
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/59080
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.12 (2023) date: 2023-09-27 nr.10 p.1-19
dc.subjectatherogenic profile
dc.subjectcardiovascular risk
dc.subjecthigh-density lipoproteins
dc.subjectpregnancy
dc.subjectvascular dysfunction
dc.titleMaternal Supraphysiological Hypercholesterolemia Is Accompanied by Shifts in the Composition and Anti-Atherogenic Functions of Maternal HDL along with Maternal Cardiovascular Risk Markers at Term of Pregnancyeng
dc.typeArticleeng
dc.typeArtículospa
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