48-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: A double-blind randomised clinical trial

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dc.coverageDOI: 10.1016/j.dental.2023.07.002
dc.creatorMatos, Thalita P.
dc.creatorÑaupari-Villasante, Romina
dc.creatorKunz, Patrícia Valeria Manozzo
dc.creatorHass, Viviane
dc.creatorReis, Alessandra
dc.creatorGutiérrez, Mario F.
dc.creatorLoguercio, Alessandro D.
dc.date2023
dc.date.accessioned2025-11-18T19:42:42Z
dc.date.available2025-11-18T19:42:42Z
dc.description<p>Objectives: This study aimed to evaluate the effect of copper nanoparticles (CuNp) on the clinical performance of a universal adhesive system used as an etch-and-rinse or self-etch strategy. Methods: A total of 216 class V (non-carious lesions) restorations were randomly placed in 36 subjects according to the following groups: ERcu, adhesive in etch-and-rinse with 0.1% CuNp; ERct, adhesive in etch-and-rinse without CuNp; SEcu, adhesive in self-etch with 0.1% CuNp; and Sect, adhesive in self-etch without CuNp. Restorations were evaluated at baseline and at 6, 12, 18, 36, and 48 months, using the FDI and USPHS criteria. Appropriate statistical analyses were performed (α = 0.05). Results: After 48 months, 14 restorations were lost (two for ERcu, five for SEcu, and seven for SEct) and the retention rates (95% confidence interval [CI]) were 74.1% for ERcu (95% CI 61.1–83.8); 81.5% for ERct (95% CI 69.2–89.6); 64.8% (95% CI 51.5–76.2) for SEcu; and 64.8% (95% CI 51.5–76.2) for SEct, with statistical differences between SEct vs. ERct and SEcu vs. ERct (p &lt; 0.05). No significant differences between the groups were observed when the secondary parameters were evaluated (p &gt; 0.05). Nineteen restorations (two for ERcu, two for ERct, six for SEcu, and nine for SEct) showed minor marginal staining, and 44 restorations (7 for ERcu, 8 for ERct, 14 for SEcu, and 15 for SEct) presented minimal marginal adaptation defects. Significance: This is the first long-term clinical trial to show that the addition of CuNp to a universal adhesive system does not affect clinical performance.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/071447e0-f132-44b2-8ab7-0bc0d4a3eaff
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/52493
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.39 (2023) nr.9 p.820-830
dc.subjectClinical trial
dc.subjectCopper nanoparticles
dc.subjectLongevity
dc.subjectNon-carious cervical lesion
dc.subjectUniversal adhesive system
dc.title48-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: A double-blind randomised clinical trialeng
dc.typeArticleeng
dc.typeArtículospa
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