Exploring the therapeutic potential of the mitochondrial transfer-associated enzymatic machinery in brain degeneration

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dc.coverageDOI: 10.3389/fphys.2023.1217815
dc.creatorLuque-Campos, Noymar
dc.creatorRiquelme, Ricardo
dc.creatorMolina, Luis
dc.creatorCanedo-Marroquín, Gisela
dc.creatorVega-Letter, Ana María
dc.creatorLuz-Crawford, Patricia
dc.creatorBustamante-Barrientos, Felipe A.
dc.date2023
dc.date.accessioned2025-11-18T19:55:01Z
dc.date.available2025-11-18T19:55:01Z
dc.description<p>Mitochondrial dysfunction is a central event in the pathogenesis of several degenerative brain disorders. It entails fission and fusion dynamics disruption, progressive decline in mitochondrial clearance, and uncontrolled oxidative stress. Many therapeutic strategies have been formulated to reverse these alterations, including replacing damaged mitochondria with healthy ones. Spontaneous mitochondrial transfer is a naturally occurring process with different biological functions. It comprises mitochondrial donation from one cell to another, carried out through different pathways, such as the formation and stabilization of tunneling nanotubules and Gap junctions and the release of extracellular vesicles with mitochondrial cargoes. Even though many aspects of regulating these mechanisms still need to be discovered, some key enzymatic regulators have been identified. This review summarizes the current knowledge on mitochondrial dysfunction in different neurodegenerative disorders. Besides, we analyzed the usage of mitochondrial transfer as an endogenous revitalization tool, emphasizing the enzyme regulators that govern this mechanism. Going deeper into this matter would be helpful to take advantage of the therapeutic potential of mitochondrial transfer.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/2abee892-2c1d-4e6a-ba66-7a88b65258f5
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/59049
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.14 (2023) date: 2023-07-27 p.1-14
dc.subjectcellular therapy
dc.subjectdegenerative brain disorders
dc.subjectenzymes
dc.subjectfission and fusion
dc.subjectmitochondrial dysfunction
dc.subjectmitochondrial transfer
dc.subjectmitophagy
dc.subjectoxidative damage
dc.titleExploring the therapeutic potential of the mitochondrial transfer-associated enzymatic machinery in brain degenerationeng
dc.typeReview articleeng
dc.typeArtículo de revisiónspa
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