Antimicrobial capacity of Leucocyte-and Platelet Rich Fibrin against periodontal pathogens

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dc.coverageDOI: 10.1038/s41598-019-44755-6
dc.creatorCastro, Ana B.
dc.creatorHerrero, Esteban R.
dc.creatorSlomka, Vera
dc.creatorPinto, Nelson
dc.creatorTeughels, Wim
dc.creatorQuirynen, Marc
dc.date2019
dc.date.accessioned2025-11-18T19:40:24Z
dc.date.available2025-11-18T19:40:24Z
dc.description<p>Various studies have described the biological properties of the Leucocyte- and Platelet Rich Fibrin (L-PRF) such as the antimicrobial effect against wound bacteria, but less is known about the effect against periodontal pathogens. The aim of this study was to evaluate the antibacterial properties of the L-PRF membrane and L-PRF exudate against the main periopathogens cultured on agar plates and in planktonic solution. This study demonstrated the antibacterial effect of the L-PRF membrane against P. intermedia, F. nucleatum, and A. actinomycetemcomitans, but especially against P. gingivalis. The L-PRF exudate also showed a strong inhibition against P. gingivalis on agar plates. No inhibition could be observed for the other bacterial strains. Moreover, L-PRF exudate decreased the number of viable P.gingivalis in a planktonic solution in a dose-dependent way. However, A. actinomycetemcomitans showed an increased growth in planktonic solution when in contact with the L-PRF exudate.</p>eng
dc.descriptionVarious studies have described the biological properties of the Leucocyte- and Platelet Rich Fibrin (L-PRF) such as the antimicrobial effect against wound bacteria, but less is known about the effect against periodontal pathogens. The aim of this study was to evaluate the antibacterial properties of the L-PRF membrane and L-PRF exudate against the main periopathogens cultured on agar plates and in planktonic solution. This study demonstrated the antibacterial effect of the L-PRF membrane against P. intermedia, F. nucleatum, and A. actinomycetemcomitans, but especially against P. gingivalis. The L-PRF exudate also showed a strong inhibition against P. gingivalis on agar plates. No inhibition could be observed for the other bacterial strains. Moreover, L-PRF exudate decreased the number of viable P.gingivalis in a planktonic solution in a dose-dependent way. However, A. actinomycetemcomitans showed an increased growth in planktonic solution when in contact with the L-PRF exudate.spa
dc.identifierhttps://investigadores.uandes.cl/en/publications/34d06257-a9bf-4ad8-bb02-c679af8fab79
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/51270
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.9 (2019) date: 2019-12-01 nr.1 p.1-8
dc.subjectActinobacillus-actinomycetemcomitans
dc.subjectDental plaque
dc.subjectPlasma
dc.subjectGrowth
dc.subjectCoaggregation
dc.subjectGingipains
dc.subjectTherapies
dc.subjectBiofilm
dc.subjectRhbmp-2
dc.titleAntimicrobial capacity of Leucocyte-and Platelet Rich Fibrin against periodontal pathogenseng
dc.typeArticleeng
dc.typeArtículospa
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